Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 43752..44277 Replicon plasmid unnamed2
Accession NZ_CP026054
Organism Salmonella enterica strain FDAARGOS_70

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag MC58_RS24450 Protein ID WP_001159863.1
Coordinates 43972..44277 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag MC58_RS24445 Protein ID WP_000813641.1
Coordinates 43752..43970 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC58_RS24415 39367..39753 + 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -
MC58_RS24420 39806..39967 + 162 WP_015059604.1 hypothetical protein -
MC58_RS24425 40294..41283 - 990 WP_000461382.1 RepB family plasmid replication initiator protein -
MC58_RS24430 41777..42072 - 296 Protein_56 cytoplasmic protein -
MC58_RS24845 42084..42512 + 429 Protein_57 hypothetical protein -
MC58_RS24440 42556..43077 - 522 WP_077681952.1 hypothetical protein -
MC58_RS24445 43752..43970 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
MC58_RS24450 43972..44277 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
MC58_RS24455 44279..44569 + 291 WP_001266176.1 hypothetical protein -
MC58_RS24460 44566..45087 + 522 WP_000198608.1 hypothetical protein -
MC58_RS24465 45122..45904 + 783 WP_000082169.1 site-specific integrase -
MC58_RS24470 45913..46626 + 714 WP_000545756.1 EAL domain-containing protein -
MC58_RS24475 46630..47139 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
MC58_RS24480 47133..47618 + 486 WP_000905606.1 membrane protein -
MC58_RS24485 47895..48182 - 288 WP_071530243.1 hypothetical protein -
MC58_RS24490 48338..48898 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59363 59363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T92961 WP_001159863.1 NZ_CP026054:43972-44277 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T92961 NZ_CP026054:43972-44277 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT92961 WP_000813641.1 NZ_CP026054:43752-43970 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT92961 NZ_CP026054:43752-43970 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References