Detailed information of TA system TA092960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2437162..2437763
• Replicon: chromosome
• Accession: NZ_CP026051
• Organism: Proteus mirabilis strain FDAARGOS_67

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: MC53_RS11220
• Protein ID: WP_017826987.1
• Coordinates: 2437162..2437545 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: MC53_RS11225
• Protein ID: WP_004246496.1
• Coordinates: 2437542..2437763 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC53_RS11200	2433095..2433658	+	564	WP_012368640.1	methyltransferase	-
MC53_RS11205	2433934..2434833	+	900	WP_036919439.1	N-acetylmuramic acid 6-phosphate etherase	-
MC53_RS11210	2435190..2436428	-	1239	WP_036919441.1	HipA domain-containing protein	-
MC53_RS11215	2436441..2436755	-	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
MC53_RS11220	2437162..2437545	-	384	WP_017826987.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MC53_RS11225	2437542..2437763	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MC53_RS11230	2438044..2438907	-	864	WP_004249947.1	YicC family protein	-
MC53_RS11235	2439034..2439750	+	717	WP_004249946.1	ribonuclease PH	-
MC53_RS11240	2439832..2440476	+	645	WP_036919444.1	orotate phosphoribosyltransferase	-
MC53_RS11245	2440795..2441400	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
MC53_RS11250	2441520..2441978	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14481.57 Da
• Isoelectric Point: 8.5125

>T92960 WP_017826987.1 NZ_CP026051:c2437545-2437162 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMPDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T92960 NZ_CP026051:c2437545-2437162 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGCC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT92960 WP_004246496.1 NZ_CP026051:c2437763-2437542 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT92960 NZ_CP026051:c2437763-2437542 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCTAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9