Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5070439..5071070 Replicon chromosome
Accession NZ_CP026050
Organism Serratia marcescens strain FDAARGOS_65

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag MC51_RS23825 Protein ID WP_033640020.1
Coordinates 5070672..5071070 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag MC51_RS23820 Protein ID WP_041035628.1
Coordinates 5070439..5070672 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC51_RS23795 5065591..5067207 + 1617 WP_033653630.1 Tar ligand binding domain-containing protein -
MC51_RS23800 5067245..5068117 + 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
MC51_RS23805 5068117..5069166 + 1050 WP_033635003.1 chemotaxis response regulator protein-glutamate methylesterase -
MC51_RS23810 5069269..5069658 + 390 WP_004934862.1 chemotaxis response regulator CheY -
MC51_RS23815 5069669..5070313 + 645 WP_004934858.1 protein phosphatase CheZ -
MC51_RS23820 5070439..5070672 + 234 WP_041035628.1 antitoxin Antitoxin
MC51_RS23825 5070672..5071070 + 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
MC51_RS23830 5071200..5072351 + 1152 WP_015378261.1 flagellar type III secretion system protein FlhB -
MC51_RS23835 5072344..5074422 + 2079 WP_033635001.1 flagellar biosynthesis protein FlhA -
MC51_RS23840 5074422..5074826 + 405 WP_047571543.1 flagellar protein FlhE -
MC51_RS23845 5075155..5075970 + 816 WP_047571544.1 5'-nucleotidase, lipoprotein e(P4) family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T92955 WP_033640020.1 NZ_CP026050:5070672-5071070 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T92955 NZ_CP026050:5070672-5071070 [Serratia marcescens]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT92955 WP_041035628.1 NZ_CP026050:5070439-5070672 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT92955 NZ_CP026050:5070439-5070672 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References