Detailed information of TA system TA092953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4349431..4350087
• Replicon: chromosome
• Accession: NZ_CP026050
• Organism: Serratia marcescens strain FDAARGOS_65

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2V4G0W2
• Locus tag: MC51_RS20485
• Protein ID: WP_041036282.1
• Coordinates: 4349698..4350087 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: MC51_RS20480
• Protein ID: WP_004941563.1
• Coordinates: 4349431..4349694 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC51_RS20460	4344467..4345681	-	1215	WP_047570971.1	D-galactonate dehydratase family protein	-
MC51_RS20465	4345848..4346753	-	906	WP_033635546.1	lipid kinase YegS	-
MC51_RS20470	4347220..4348572	-	1353	WP_033635545.1	tRNA 5-hydroxyuridine modification protein YegQ	-
MC51_RS20475	4348753..4349091	-	339	WP_033648841.1	YegP family protein	-
MC51_RS20480	4349431..4349694	+	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MC51_RS20485	4349698..4350087	+	390	WP_041036282.1	type II toxin-antitoxin system VapC family toxin	Toxin
MC51_RS20490	4350095..4350811	-	717	WP_033635542.1	two-component system response regulator BaeR	-
MC51_RS20495	4350811..4352193	-	1383	WP_033635541.1	two-component system sensor histidine kinase BaeS	-
MC51_RS20500	4352190..4353620	-	1431	WP_047570973.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14309.56 Da
• Isoelectric Point: 7.8786

>T92953 WP_041036282.1 NZ_CP026050:4349698-4350087 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T92953 NZ_CP026050:4349698-4350087 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT92953 WP_004941563.1 NZ_CP026050:4349431-4349694 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT92953 NZ_CP026050:4349431-4349694 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2V4G0W2