Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3942615..3943284 Replicon chromosome
Accession NZ_CP026050
Organism Serratia marcescens strain FDAARGOS_65

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MC51_RS18530 Protein ID WP_047570653.1
Coordinates 3942862..3943284 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag MC51_RS18525 Protein ID WP_004931679.1
Coordinates 3942615..3942881 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC51_RS18500 3938182..3939108 + 927 WP_038871218.1 ribokinase -
MC51_RS18505 3939149..3939757 - 609 WP_047570649.1 HD domain-containing protein -
MC51_RS18510 3939941..3940615 + 675 WP_033639467.1 hemolysin III family protein -
MC51_RS18515 3940766..3941263 + 498 WP_033649451.1 DUF2165 domain-containing protein -
MC51_RS18520 3941302..3942294 - 993 WP_047570651.1 tRNA-modifying protein YgfZ -
MC51_RS18525 3942615..3942881 + 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
MC51_RS18530 3942862..3943284 + 423 WP_047570653.1 protein YgfX Toxin
MC51_RS18535 3943284..3943979 + 696 WP_047570655.1 two-component system response regulator CreB -
MC51_RS18540 3943976..3945394 + 1419 WP_047570657.1 two-component system sensor histidine kinase CreC -
MC51_RS18545 3945475..3946839 + 1365 WP_047570659.1 cell envelope integrity protein CreD -
MC51_RS18550 3946877..3947395 - 519 WP_004931683.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3890906..3949340 58434


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16457.56 Da        Isoelectric Point: 10.8114

>T92951 WP_047570653.1 NZ_CP026050:3942862-3943284 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLSHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Download         Length: 423 bp

>T92951 NZ_CP026050:3942862-3943284 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGAGCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGTTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT92951 WP_004931679.1 NZ_CP026050:3942615-3942881 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT92951 NZ_CP026050:3942615-3942881 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References