Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2999844..3000445 Replicon chromosome
Accession NZ_CP026050
Organism Serratia marcescens strain FDAARGOS_65

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag MC51_RS14120 Protein ID WP_033649548.1
Coordinates 3000065..3000445 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag MC51_RS14115 Protein ID WP_004933932.1
Coordinates 2999844..3000065 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC51_RS14100 2994992..2995969 + 978 WP_047569939.1 glyoxylate/hydroxypyruvate reductase GhrB -
MC51_RS25010 2995971..2996123 - 153 WP_019455508.1 hypothetical protein -
MC51_RS14105 2996320..2998383 + 2064 WP_047569940.1 alpha-amylase -
MC51_RS14110 2998519..2999769 + 1251 WP_033645138.1 valine--pyruvate transaminase -
MC51_RS14115 2999844..3000065 + 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
MC51_RS14120 3000065..3000445 + 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
MC51_RS14125 3000456..3002114 - 1659 WP_047569941.1 putative transporter -
MC51_RS14130 3002281..3002709 - 429 WP_004933922.1 heat shock chaperone IbpB -
MC51_RS14135 3002810..3003223 - 414 WP_047569943.1 heat shock chaperone IbpA -
MC51_RS14140 3003534..3003881 + 348 WP_033636538.1 YceK/YidQ family lipoprotein -
MC51_RS14145 3003912..3005192 - 1281 WP_047569945.1 DUF3748 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T92950 WP_033649548.1 NZ_CP026050:3000065-3000445 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T92950 NZ_CP026050:3000065-3000445 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT92950 WP_004933932.1 NZ_CP026050:2999844-3000065 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT92950 NZ_CP026050:2999844-3000065 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References