Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2959026..2959561 Replicon chromosome
Accession NZ_CP026050
Organism Serratia marcescens strain FDAARGOS_65

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D971
Locus tag MC51_RS13945 Protein ID WP_033636570.1
Coordinates 2959026..2959301 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D6BJ42
Locus tag MC51_RS13950 Protein ID WP_047569919.1
Coordinates 2959301..2959561 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC51_RS13925 2954847..2955839 - 993 WP_047569913.1 acyltransferase -
MC51_RS13930 2956057..2957304 + 1248 WP_047571709.1 MFS transporter -
MC51_RS13935 2957355..2957981 - 627 WP_047569917.1 LysE family translocator -
MC51_RS13940 2958103..2959014 + 912 WP_033636572.1 LysR family transcriptional regulator -
MC51_RS13945 2959026..2959301 - 276 WP_033636570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MC51_RS13950 2959301..2959561 - 261 WP_047569919.1 ribbon-helix-helix domain-containing protein Antitoxin
MC51_RS13955 2959644..2961485 - 1842 WP_047569921.1 selenocysteine-specific translation elongation factor -
MC51_RS13960 2961482..2962876 - 1395 WP_047569922.1 L-seryl-tRNA(Sec) selenium transferase -
MC51_RS13965 2962945..2963550 - 606 WP_047569924.1 glutathione S-transferase -
MC51_RS13970 2963591..2964241 - 651 WP_033649530.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10578.32 Da        Isoelectric Point: 10.3377

>T92949 WP_033636570.1 NZ_CP026050:c2959301-2959026 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T92949 NZ_CP026050:c2959301-2959026 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9683.98 Da        Isoelectric Point: 4.5084

>AT92949 WP_047569919.1 NZ_CP026050:c2959561-2959301 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT92949 NZ_CP026050:c2959561-2959301 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D971

Antitoxin

Source ID Structure
AlphaFold DB A0A7D6BJ42

References