Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1871775..1872396 Replicon chromosome
Accession NZ_CP026050
Organism Serratia marcescens strain FDAARGOS_65

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag MC51_RS08800 Protein ID WP_004940313.1
Coordinates 1872193..1872396 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag MC51_RS08795 Protein ID WP_004940312.1
Coordinates 1871775..1872143 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC51_RS08765 1867870..1868124 + 255 WP_004940303.1 type B 50S ribosomal protein L31 -
MC51_RS08770 1868137..1868277 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
MC51_RS08775 1868384..1869262 - 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
MC51_RS08780 1869288..1870145 - 858 WP_033637343.1 metal ABC transporter permease -
MC51_RS08785 1870142..1870855 - 714 WP_047568987.1 ABC transporter ATP-binding protein -
MC51_RS08790 1871263..1871616 + 354 WP_033653245.1 hypothetical protein -
MC51_RS08795 1871775..1872143 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
MC51_RS08800 1872193..1872396 + 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
MC51_RS08805 1872693..1873211 - 519 WP_047568991.1 cytochrome b/b6 domain-containing protein -
MC51_RS08810 1873264..1874700 - 1437 WP_047568993.1 N-acetylglucosamine-binding protein GbpA -
MC51_RS08815 1874954..1875316 + 363 WP_033653248.1 type II secretion system pilot lipoprotein GspS -
MC51_RS08820 1875313..1876128 - 816 WP_052133456.1 A24 family peptidase -
MC51_RS08825 1876164..1876610 - 447 WP_047568994.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T92946 WP_004940313.1 NZ_CP026050:1872193-1872396 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T92946 NZ_CP026050:1872193-1872396 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT92946 WP_004940312.1 NZ_CP026050:1871775-1872143 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT92946 NZ_CP026050:1871775-1872143 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCATCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References