Detailed information of TA system TA092921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1308960..1309777
• Replicon: chromosome
• Accession: NZ_CP026046
• Organism: Morganella morganii strain FDAARGOS_63

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: MC49_RS06195
• Protein ID: WP_015422406.1
• Coordinates: 1309271..1309777 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: MC49_RS06190
• Protein ID: WP_032097998.1
• Coordinates: 1308960..1309268 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC49_RS06165	1304268..1304474	-	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-
MC49_RS06170	1304582..1305574	-	993	WP_032098000.1	inner membrane protein YhjD	-
MC49_RS06175	1305986..1306375	-	390	WP_004236536.1	DUF1090 domain-containing protein	-
MC49_RS06180	1306565..1307407	+	843	WP_004236535.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
MC49_RS06185	1307476..1308828	+	1353	WP_032098064.1	glutathione-disulfide reductase	-
MC49_RS06190	1308960..1309268	+	309	WP_032097998.1	DUF1778 domain-containing protein	Antitoxin
MC49_RS06195	1309271..1309777	+	507	WP_015422406.1	GNAT family N-acetyltransferase	Toxin
MC49_RS19310	1309785..1310031	-	247	Protein_1181	hypothetical protein	-
MC49_RS06200	1310028..1310549	-	522	WP_015422407.1	isopentenyl-diphosphate Delta-isomerase	-
MC49_RS06205	1310677..1310979	-	303	WP_004240743.1	exported protein precursor	-
MC49_RS06210	1311194..1312309	-	1116	WP_048821882.1	molybdenum cofactor guanylyltransferase MobA	-
MC49_RS06215	1312512..1312781	+	270	WP_036415677.1	YihD family protein	-
MC49_RS06220	1312781..1313776	+	996	WP_004236526.1	serine/threonine protein kinase	-
MC49_RS06225	1313795..1314418	+	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18565.43 Da
• Isoelectric Point: 9.9508

>T92921 WP_015422406.1 NZ_CP026046:1309271-1309777 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T92921 NZ_CP026046:1309271-1309777 [Morganella morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAA
ATTCCGGTTATCCTGCCGGGACGTCTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCGGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGCATCTATTCTGAATAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11469.12 Da
• Isoelectric Point: 8.6397

>AT92921 WP_032097998.1 NZ_CP026046:1308960-1309268 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLAKAPWEK

Nucleotide

• Length: 309 bp

>AT92921 NZ_CP026046:1308960-1309268 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGGCGAAGGCGCCGTGGGAGAAGTAA