Detailed information of TA system TA092905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 1424363..1424949
• Replicon: chromosome
• Accession: NZ_CP026045
• Organism: Citrobacter freundii strain FDAARGOS_61

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: MC47_RS07025
• Protein ID: WP_047408095.1
• Coordinates: 1424581..1424949 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: MC47_RS07020
• Protein ID: WP_032945249.1
• Coordinates: 1424363..1424584 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC47_RS06990	1419726..1421003	+	1278	WP_043018609.1	branched chain amino acid ABC transporter permease LivM	-
MC47_RS06995	1421000..1421767	+	768	WP_047408088.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
MC47_RS07000	1421785..1422498	+	714	WP_087050797.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
MC47_RS07005	1422626..1423372	+	747	WP_043018608.1	hypothetical protein	-
MC47_RS07010	1423475..1423756	+	282	WP_043018607.1	hypothetical protein	-
MC47_RS07015	1423897..1424304	+	408	WP_047408091.1	hypothetical protein	-
MC47_RS07020	1424363..1424584	+	222	WP_032945249.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MC47_RS07025	1424581..1424949	+	369	WP_047408095.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MC47_RS07030	1425207..1426523	+	1317	WP_043018605.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
MC47_RS07035	1426626..1427513	+	888	WP_043018604.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
MC47_RS07040	1427510..1428355	+	846	WP_003023450.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
MC47_RS07050	1428623..1429693	+	1071	WP_047408101.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1419726..1430433	10707

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13503.78 Da
• Isoelectric Point: 6.7249

>T92905 WP_047408095.1 NZ_CP026045:1424581-1424949 [Citrobacter freundii]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEALMYRVLNQIEYEGVTDVWLMAAMHLLAISRGHIFNDSNKRTALF
ITLLFLKRNGIAVPANPDFVAMTVEAAAGQLTLEQIASRLRG

Nucleotide

• Length: 369 bp

>T92905 NZ_CP026045:1424581-1424949 [Citrobacter freundii]
ATGACCCTACAAATTATCTCAGCGGAAGAGATAATCCAGTTTCACGACAGGCTGCTACGCGTAACGCCTGGCGTTGCGGG
CATGCCTGATCCTGGTCGTGCTGAAGCGCTGATGTATCGAGTGTTAAATCAAATTGAATACGAAGGTGTGACCGACGTGT
GGTTGATGGCCGCAATGCATTTACTGGCTATCTCACGTGGGCATATTTTTAATGATAGTAACAAACGTACCGCTTTGTTT
ATTACGTTACTGTTTTTAAAGCGTAACGGGATAGCTGTGCCTGCAAACCCGGATTTTGTCGCCATGACGGTTGAAGCGGC
TGCGGGCCAACTGACGCTGGAACAAATAGCCTCTCGCCTGCGTGGTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8292.38 Da
• Isoelectric Point: 4.7906

>AT92905 WP_032945249.1 NZ_CP026045:1424363-1424584 [Citrobacter freundii]
MRTMNYSEARQNLAEVLESAVTGVPVTITRRGHKPAVIISAEEFERYQAARLDDEFADIMMVHGNEIRELADK

Nucleotide

• Length: 222 bp

>AT92905 NZ_CP026045:1424363-1424584 [Citrobacter freundii]
ATGCGTACCATGAACTATAGCGAAGCCCGACAAAATCTGGCTGAAGTACTGGAGAGCGCTGTCACCGGCGTTCCTGTCAC
TATTACACGTCGTGGTCATAAGCCTGCCGTAATCATCAGCGCGGAAGAGTTCGAACGCTATCAGGCTGCAAGACTTGATG
ATGAATTTGCGGATATCATGATGGTACATGGTAATGAAATCAGGGAGCTGGCGGATAAATGA