Detailed information of TA system TA092903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 692172..692707
• Replicon: chromosome
• Accession: NZ_CP026045
• Organism: Citrobacter freundii strain FDAARGOS_61

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MC47_RS03465
• Protein ID: WP_047406935.1
• Coordinates: 692420..692707 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4BKM9
• Locus tag: MC47_RS03460
• Protein ID: WP_006688247.1
• Coordinates: 692172..692423 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC47_RS03420	687355..688041	+	687	WP_047413307.1	phosphonate C-P lyase system protein PhnL	-
MC47_RS03425	688038..689174	+	1137	WP_047406916.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
MC47_RS03430	689177..689731	+	555	WP_043018118.1	ribose 1,5-bisphosphokinase	-
MC47_RS03435	689718..690152	+	435	WP_043018117.1	aminoalkylphosphonate N-acetyltransferase	-
MC47_RS03440	690161..690919	+	759	WP_047406919.1	phosphonate metabolism protein PhnP	-
MC47_RS03445	690988..691473	+	486	WP_047406923.1	membrane protein	-
MC47_RS03450	691542..691793	+	252	WP_047406926.1	hypothetical protein	-
MC47_RS03455	691765..692094	+	330	WP_047406929.1	phosphotyrosine protein phosphatase	-
MC47_RS03460	692172..692423	+	252	WP_006688247.1	plasmid stabilization protein	Antitoxin
MC47_RS03465	692420..692707	+	288	WP_047406935.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC47_RS03470	692704..693030	-	327	WP_047406937.1	hypothetical protein	-
MC47_RS03475	693100..695364	-	2265	WP_047406940.1	hybrid sensor histidine kinase/response regulator	-
MC47_RS03485	695479..697002	+	1524	WP_047406943.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11074.03 Da
• Isoelectric Point: 10.2540

>T92903 WP_047406935.1 NZ_CP026045:692420-692707 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDLAIQQQFAKKLKKCCENPHVPSAKLRGIKDCYKIKLRTSGFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Nucleotide

• Length: 288 bp

>T92903 NZ_CP026045:692420-692707 [Citrobacter freundii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTTGATTTAGCCATTCAGCAGCAATTTGC
CAAAAAACTAAAGAAATGCTGTGAAAATCCGCATGTTCCTTCCGCAAAGCTCAGGGGAATAAAAGATTGCTATAAAATCA
AACTGCGAACATCAGGGTTTCGTCTTGTTTATCAAGTCATTGACGACACCCTGGTCATCGCGGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTCTATAACCTTGCCAGCGAAAGATTGCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 4.2965

>AT92903 WP_006688247.1 NZ_CP026045:692172-692423 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT92903 NZ_CP026045:692172-692423 [Citrobacter freundii]
ATGCCGCATATCATTTTAAGCGATACCACCGCCAGCGTGAGTGAGCTGAAAAAGAACCCGATGGCGACTGTTAGCGCAGG
TGATGGCTTTCCGGTCGCCATCCTGAACCGTAACCAGCCCGCCTTTTATTGTGTGCCAGCAGAGCTTTACGAAAAAATGC
TTGATGCGCTGGACGACCAACAGCTGGTTAAATTAGTCCATGAACGTAGCCAACAACCCCTGGTGGATGTGGATCTGGAC
AGCTACTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A7X1BT32