Detailed information of TA system TA092901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 4022030..4022729
• Replicon: chromosome
• Accession: NZ_CP026044
• Organism: Proteus mirabilis strain FDAARGOS_60

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MC46_RS18965
• Protein ID: WP_036908699.1
• Coordinates: 4022343..4022729 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: MC46_RS18960
• Protein ID: WP_004246828.1
• Coordinates: 4022030..4022350 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC46_RS18930	4017161..4017436	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
MC46_RS18935	4017491..4018114	-	624	WP_004246821.1	guanylate kinase	-
MC46_RS18940	4018415..4019032	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
MC46_RS18945	4019169..4020455	+	1287	WP_004249090.1	DUF3748 domain-containing protein	-
MC46_RS18950	4020670..4021554	+	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
MC46_RS18955	4021547..4021981	+	435	WP_004246827.1	hypothetical protein	-
MC46_RS18960	4022030..4022350	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
MC46_RS18965	4022343..4022729	-	387	WP_036908699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC46_RS18970	4022891..4024963	-	2073	WP_036908701.1	glycine--tRNA ligase subunit beta	-
MC46_RS18975	4024973..4025878	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
MC46_RS18980	4026129..4026710	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14236.60 Da
• Isoelectric Point: 10.1757

>T92901 WP_036908699.1 NZ_CP026044:c4022729-4022343 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKGLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T92901 NZ_CP026044:c4022729-4022343 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGGTCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT92901 WP_004246828.1 NZ_CP026044:c4022350-4022030 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT92901 NZ_CP026044:c4022350-4022030 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGAATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97