Detailed information of TA system TA092899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 3708030..3708631
• Replicon: chromosome
• Accession: NZ_CP026044
• Organism: Proteus mirabilis strain FDAARGOS_60

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: MC46_RS17570
• Protein ID: WP_017826987.1
• Coordinates: 3708248..3708631 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: MC46_RS17565
• Protein ID: WP_004246496.1
• Coordinates: 3708030..3708251 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC46_RS17540	3703815..3704273	+	459	WP_004246490.1	dUTP diphosphatase	-
MC46_RS17545	3704393..3704998	+	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
MC46_RS17550	3705317..3705961	-	645	WP_036908595.1	orotate phosphoribosyltransferase	-
MC46_RS17555	3706043..3706759	-	717	WP_004249760.1	ribonuclease PH	-
MC46_RS17560	3706886..3707749	+	864	WP_004249947.1	YicC family protein	-
MC46_RS17565	3708030..3708251	+	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MC46_RS17570	3708248..3708631	+	384	WP_017826987.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MC46_RS17575	3709039..3709353	+	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
MC46_RS17580	3709653..3710552	-	900	WP_004246500.1	N-acetylmuramic acid 6-phosphate etherase	-
MC46_RS17585	3710828..3711391	-	564	WP_012368640.1	methyltransferase	-
MC46_RS17590	3711891..3712997	+	1107	WP_004249769.1	aspartate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14481.57 Da
• Isoelectric Point: 8.5125

>T92899 WP_017826987.1 NZ_CP026044:3708248-3708631 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMPDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T92899 NZ_CP026044:3708248-3708631 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGCC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT92899 WP_004246496.1 NZ_CP026044:3708030-3708251 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT92899 NZ_CP026044:3708030-3708251 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9