Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3003820..3004480 Replicon chromosome
Accession NZ_CP026044
Organism Proteus mirabilis strain FDAARGOS_60

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MC46_RS14135 Protein ID WP_004245133.1
Coordinates 3004055..3004480 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E3RLN2
Locus tag MC46_RS14130 Protein ID WP_004245128.1
Coordinates 3003820..3004062 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC46_RS14110 2999794..3000759 + 966 WP_004245124.1 ribose ABC transporter permease -
MC46_RS14115 3000799..3001689 + 891 WP_004247214.1 ribose ABC transporter substrate-binding protein RbsB -
MC46_RS14120 3001766..3002692 + 927 WP_004245126.1 ribokinase -
MC46_RS14125 3002697..3003704 + 1008 WP_012367471.1 ribose operon transcriptional repressor RbsR -
MC46_RS14130 3003820..3004062 + 243 WP_004245128.1 hypothetical protein Antitoxin
MC46_RS14135 3004055..3004480 + 426 WP_004245133.1 type II toxin-antitoxin system VapC family toxin Toxin
MC46_RS14140 3004908..3005243 + 336 WP_004245134.1 phnA family protein -
MC46_RS14145 3005329..3006309 - 981 WP_004245135.1 thiamine-phosphate kinase -
MC46_RS14150 3006403..3006816 - 414 WP_004245136.1 transcription antitermination factor NusB -
MC46_RS14155 3006845..3007315 - 471 WP_004245137.1 6,7-dimethyl-8-ribityllumazine synthase -
MC46_RS14160 3007528..3008685 - 1158 WP_049255083.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
MC46_RS14165 3008734..3009183 - 450 WP_004245139.1 transcriptional regulator NrdR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15924.18 Da        Isoelectric Point: 6.4879

>T92898 WP_004245133.1 NZ_CP026044:3004055-3004480 [Proteus mirabilis]
MIKYLLDTNIVIFTIKRKPEFLLPKFNQHAEQLAISTITLAELIFGAEKSVNPAKNLATVNDFVSRLTVLSYDDLAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTVINSDPQTD

Download         Length: 426 bp

>T92898 NZ_CP026044:3004055-3004480 [Proteus mirabilis]
ATGATTAAATACCTATTAGATACAAATATTGTTATATTCACTATTAAACGCAAGCCTGAGTTTTTATTACCAAAATTCAA
CCAACATGCTGAACAATTAGCTATTTCTACAATTACACTCGCTGAGCTCATTTTTGGTGCTGAAAAAAGTGTAAATCCAG
CCAAAAACTTAGCTACGGTTAACGACTTTGTTTCTCGACTGACTGTTTTATCTTACGATGACTTAGCAGCTTTTCATTAT
GGAGACATTAGAGCAACACTAGAAAAACAGGGAAAACGCATTGGTGATAACGACTTACATATAGCAGCACATGCTAGAAG
TAAGGGGCTAATAGTCGTTACCAATAATACTCGAGAATTTGAAAGAGTTGATGGTTTAAGAATTGAGGATTGGACCGTTA
TTAACTCAGACCCCCAAACTGATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9390.48 Da        Isoelectric Point: 4.6182

>AT92898 WP_004245128.1 NZ_CP026044:3003820-3004062 [Proteus mirabilis]
MIQYGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQATSERESFDD

Download         Length: 243 bp

>AT92898 NZ_CP026044:3003820-3004062 [Proteus mirabilis]
ATGATCCAGTATGGCAAAGTATTTATGAGCAATAGAACACAAAATGTTCGATTACCCGCTGAGACTCGATTTCCGGATGA
TGTAAAAGAAGTTTTTGTTCGCGTCAAAGGCAAAGAGAGAATAATCACACCTATACAAAATGCATGGGATAGCTTTTTCT
TATCAGAAAAGTCTGTAACAGATGATTTCTTATCTGAAAGGCCTGATCAAGCCACAAGTGAAAGAGAATCCTTTGATGAT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References