Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2856514..2857310 Replicon chromosome
Accession NZ_CP026044
Organism Proteus mirabilis strain FDAARGOS_60

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag MC46_RS13505 Protein ID WP_036894284.1
Coordinates 2856514..2857026 (-) Length 171 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag MC46_RS13510 Protein ID WP_036894282.1
Coordinates 2857023..2857310 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC46_RS13480 2852093..2852851 - 759 WP_036908334.1 DNA polymerase III subunit epsilon -
MC46_RS13485 2852917..2853396 + 480 WP_004244975.1 ribonuclease HI -
MC46_RS13490 2853421..2854134 - 714 WP_017827399.1 methyltransferase domain-containing protein -
MC46_RS13495 2854172..2854927 + 756 WP_004244977.1 hydroxyacylglutathione hydrolase -
MC46_RS13500 2855001..2856335 + 1335 WP_036908336.1 murein transglycosylase D -
MC46_RS13505 2856514..2857026 - 513 WP_036894284.1 GNAT family N-acetyltransferase Toxin
MC46_RS13510 2857023..2857310 - 288 WP_036894282.1 DUF1778 domain-containing protein Antitoxin
MC46_RS13515 2857810..2859192 - 1383 WP_004247295.1 DASS family sodium-coupled anion symporter -
MC46_RS13520 2859512..2860813 - 1302 WP_004244982.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-87)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18393.37 Da        Isoelectric Point: 9.5973

>T92897 WP_036894284.1 NZ_CP026044:c2857026-2856514 [Proteus mirabilis]
MTLKLTAPEPLKSVHLLEGFSSGEEALDLWLKNRAMSNQNSGASRTFVTTSDNQVMGYYALSTGVISTNQAVGRFRRNMP
TDIPVILLGRLAVDTRAKGLGIGRGLVKDACHRVIQASGLVGIRGVVVHALTDDAKRFYEHIGFLPSPLDPMMLMITLSD
LQLAMGISPN

Download         Length: 513 bp

>T92897 NZ_CP026044:c2857026-2856514 [Proteus mirabilis]
ATGACATTGAAGCTAACAGCACCTGAACCACTCAAATCAGTCCATCTGCTGGAGGGTTTTTCCTCCGGAGAAGAGGCTTT
AGATCTCTGGCTAAAAAACCGGGCAATGAGTAATCAAAACTCTGGTGCGTCGCGCACTTTTGTGACCACTTCGGATAACC
AGGTAATGGGGTATTATGCCTTGTCCACAGGGGTCATAAGCACCAATCAAGCCGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATACCCGTCATTCTACTTGGCAGGCTGGCGGTTGATACAAGGGCTAAAGGTCTTGGGATCGGAAGAGGACTTGT
TAAGGATGCCTGTCATCGCGTTATTCAGGCATCAGGGCTGGTGGGCATTAGAGGGGTGGTGGTTCACGCCCTTACTGACG
ATGCAAAACGGTTCTATGAGCATATTGGCTTCTTGCCTTCGCCGCTCGACCCGATGATGCTGATGATAACGCTTAGCGAT
CTGCAACTCGCTATGGGCATTTCCCCGAACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10717.15 Da        Isoelectric Point: 5.1972

>AT92897 WP_036894282.1 NZ_CP026044:c2857310-2857023 [Proteus mirabilis]
MPTQNDVSVTRSSLNLRIKPEDKILIDRAANAVGKNRTEFVLEAARRAAEETLADLRVINVSPEVYQEFISQLDSAPESN
EALRKTMMSKSPWEK

Download         Length: 288 bp

>AT92897 NZ_CP026044:c2857310-2857023 [Proteus mirabilis]
ATGCCAACTCAAAATGATGTGAGCGTAACACGTTCATCACTGAACCTGAGAATAAAGCCGGAAGATAAAATTCTGATCGA
CCGTGCCGCTAATGCAGTGGGGAAAAACCGTACCGAGTTTGTTCTGGAAGCTGCTCGACGTGCAGCTGAAGAAACGCTGG
CAGATCTGCGAGTCATTAACGTCAGTCCCGAAGTTTACCAGGAATTTATTAGCCAGCTTGATTCAGCGCCTGAGAGCAAT
GAGGCACTACGAAAAACAATGATGTCTAAATCCCCTTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References