Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1899244..1899803 | Replicon | chromosome |
| Accession | NZ_CP026041 | ||
| Organism | Vibrio parahaemolyticus strain FDAARGOS_51 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W573 |
| Locus tag | RK51_RS10010 | Protein ID | WP_005500338.1 |
| Coordinates | 1899244..1899522 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | RK51_RS10015 | Protein ID | WP_005398409.1 |
| Coordinates | 1899519..1899803 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RK51_RS09940 | 1894296..1894406 | + | 111 | WP_081441220.1 | DUF3265 domain-containing protein | - |
| RK51_RS09945 | 1894432..1894869 | + | 438 | WP_005500331.1 | GIY-YIG nuclease family protein | - |
| RK51_RS09960 | 1895576..1895773 | + | 198 | WP_005500332.1 | hypothetical protein | - |
| RK51_RS09970 | 1896381..1896449 | + | 69 | WP_079748735.1 | DUF3265 domain-containing protein | - |
| RK51_RS09975 | 1896531..1896788 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| RK51_RS09980 | 1896776..1897078 | + | 303 | WP_005500333.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| RK51_RS09985 | 1897075..1897206 | + | 132 | WP_079767305.1 | DUF3265 domain-containing protein | - |
| RK51_RS09990 | 1897254..1897622 | + | 369 | WP_005500334.1 | VOC family protein | - |
| RK51_RS09995 | 1897779..1898618 | + | 840 | WP_005500335.1 | hypothetical protein | - |
| RK51_RS10000 | 1898767..1899120 | + | 354 | WP_005500336.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| RK51_RS25745 | 1899081..1899215 | + | 135 | WP_161612893.1 | DUF3265 domain-containing protein | - |
| RK51_RS10010 | 1899244..1899522 | - | 279 | WP_005500338.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| RK51_RS10015 | 1899519..1899803 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| RK51_RS10020 | 1900070..1900360 | + | 291 | WP_005500341.1 | YkgJ family cysteine cluster protein | - |
| RK51_RS10030 | 1901028..1902178 | + | 1151 | WP_086027884.1 | IS3 family transposase | - |
| RK51_RS10035 | 1902210..1902581 | + | 372 | Protein_1752 | pyridoxamine 5'-phosphate oxidase family protein | - |
| RK51_RS10040 | 1902949..1903395 | - | 447 | WP_005500348.1 | DUF3291 domain-containing protein | - |
| RK51_RS10045 | 1903737..1904198 | + | 462 | WP_005500350.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1814154..1903395 | 89241 | |
| - | inside | Integron | - | - | 1814678..1902714 | 88036 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10878.53 Da Isoelectric Point: 4.2597
>T92894 WP_005500338.1 NZ_CP026041:c1899522-1899244 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T92894 NZ_CP026041:c1899522-1899244 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTGATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGATATTTCGATGATTGTGTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTGATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGATATTTCGATGATTGTGTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT92894 WP_005398409.1 NZ_CP026041:c1899803-1899519 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT92894 NZ_CP026041:c1899803-1899519 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249W573 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |