Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1896531..1897078 Replicon chromosome
Accession NZ_CP026041
Organism Vibrio parahaemolyticus strain FDAARGOS_51

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5B6
Locus tag RK51_RS09980 Protein ID WP_005500333.1
Coordinates 1896776..1897078 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag RK51_RS09975 Protein ID WP_005448240.1
Coordinates 1896531..1896788 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK51_RS09890 1891827..1891952 + 126 WP_005500324.1 DUF3265 domain-containing protein -
RK51_RS09895 1891997..1892281 + 285 WP_005500325.1 nucleotide pyrophosphohydrolase -
RK51_RS09900 1892297..1892399 + 103 Protein_1729 DUF3265 domain-containing protein -
RK51_RS09905 1892426..1892698 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
RK51_RS25740 1892676..1892819 + 144 WP_109170490.1 DUF3265 domain-containing protein -
RK51_RS09915 1892850..1893146 + 297 WP_005500327.1 hypothetical protein -
RK51_RS09920 1893086..1893253 + 168 WP_086027883.1 DUF3265 domain-containing protein -
RK51_RS09925 1893283..1893663 + 381 WP_005487927.1 TonB family protein -
RK51_RS09930 1893670..1893780 + 111 WP_079861117.1 DUF3265 domain-containing protein -
RK51_RS09935 1893790..1894299 + 510 WP_005500328.1 hypothetical protein -
RK51_RS09940 1894296..1894406 + 111 WP_081441220.1 DUF3265 domain-containing protein -
RK51_RS09945 1894432..1894869 + 438 WP_005500331.1 GIY-YIG nuclease family protein -
RK51_RS09960 1895576..1895773 + 198 WP_005500332.1 hypothetical protein -
RK51_RS09970 1896381..1896449 + 69 WP_079748735.1 DUF3265 domain-containing protein -
RK51_RS09975 1896531..1896788 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK51_RS09980 1896776..1897078 + 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RK51_RS09985 1897075..1897206 + 132 WP_079767305.1 DUF3265 domain-containing protein -
RK51_RS09990 1897254..1897622 + 369 WP_005500334.1 VOC family protein -
RK51_RS09995 1897779..1898618 + 840 WP_005500335.1 hypothetical protein -
RK51_RS10000 1898767..1899120 + 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
RK51_RS25745 1899081..1899215 + 135 WP_161612893.1 DUF3265 domain-containing protein -
RK51_RS10010 1899244..1899522 - 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
RK51_RS10015 1899519..1899803 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
RK51_RS10020 1900070..1900360 + 291 WP_005500341.1 YkgJ family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1814154..1903395 89241
- inside Integron - - 1814678..1902714 88036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.65 Da        Isoelectric Point: 6.9806

>T92893 WP_005500333.1 NZ_CP026041:1896776-1897078 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T92893 NZ_CP026041:1896776-1897078 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAAAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTATTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTTTTTGTTATGCGTGCTGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT92893 WP_005448240.1 NZ_CP026041:1896531-1896788 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT92893 NZ_CP026041:1896531-1896788 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGGAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCATTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5B6

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References