Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1846192..1846751 Replicon chromosome
Accession NZ_CP026041
Organism Vibrio parahaemolyticus strain FDAARGOS_51

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5L8
Locus tag RK51_RS09460 Protein ID WP_005497247.1
Coordinates 1846192..1846470 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2ZGZ5
Locus tag RK51_RS09465 Protein ID WP_005497249.1
Coordinates 1846467..1846751 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK51_RS09410 1841904..1842023 + 120 WP_079748757.1 DUF3265 domain-containing protein -
RK51_RS09415 1842063..1842719 + 657 WP_021447340.1 Bax inhibitor-1 family protein -
RK51_RS09420 1842721..1842837 + 117 WP_161793456.1 DUF3265 domain-containing protein -
RK51_RS09425 1842874..1843383 + 510 WP_021447337.1 GNAT family N-acetyltransferase -
RK51_RS09430 1843380..1843489 + 110 Protein_1652 DUF3265 domain-containing protein -
RK51_RS09440 1844047..1844715 + 669 WP_005497242.1 GIY-YIG nuclease family protein -
RK51_RS09450 1845337..1846056 + 720 WP_021447410.1 hypothetical protein -
RK51_RS09455 1846071..1846163 + 93 WP_072036351.1 DUF3265 domain-containing protein -
RK51_RS09460 1846192..1846470 - 279 WP_005497247.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
RK51_RS09465 1846467..1846751 - 285 WP_005497249.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RK51_RS09470 1846919..1847476 + 558 WP_005497250.1 nucleotidyltransferase domain-containing protein -
RK51_RS25625 1847662..1848021 + 360 WP_005497251.1 hypothetical protein -
RK51_RS09480 1848366..1849058 + 693 WP_127463323.1 hypothetical protein -
RK51_RS09485 1849165..1849578 + 414 WP_005500273.1 hypothetical protein -
RK51_RS09490 1849565..1849690 + 126 WP_161612916.1 DUF3265 domain-containing protein -
RK51_RS09495 1850311..1850514 + 204 WP_025793489.1 hypothetical protein -
RK51_RS09500 1850693..1851169 + 477 WP_005500215.1 GNAT family N-acetyltransferase -
RK51_RS09505 1851154..1851276 + 123 WP_005500217.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1814154..1903395 89241
- inside Integron - - 1814678..1902714 88036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10914.61 Da        Isoelectric Point: 4.4755

>T92892 WP_005497247.1 NZ_CP026041:c1846470-1846192 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDEVIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPVS

Download         Length: 279 bp

>T92892 NZ_CP026041:c1846470-1846192 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCTCTCAACGATCGTGAAAAGATCTTTGAGTTTCTTTACGACTTCAACCCAGAGGCTGC
TGAAAAAACCGATGAAGTTATTGAAGCCAAAGTGGAGAACCTTCTAGAACAACCTCATATGGGAGTCCAACGAGACGGAA
TTAGAGGGCGATTGCTCATTATTCCAGAGATATCAATGATTGTTTCGTACTGGGTTGAAGGCGATATCATTCGCATTATG
CGTGTACTACACCAAAAACAAAAATTCCCTGTGAGCTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10913.25 Da        Isoelectric Point: 9.1865

>AT92892 WP_005497249.1 NZ_CP026041:c1846751-1846467 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT92892 NZ_CP026041:c1846751-1846467 [Vibrio parahaemolyticus]
ATGGACACCAGAATTCAGTTTCGTGTTGATGAAGAAACGAAACGACTAGCCCAGCAAATGGCAGAAAGCCAAGGCAGAAC
ACTAAGTGACGCTTGTCGTGAACTGACTGAACAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGATGCATGGTTAA
CTGAACAAGTTAACTTGGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGATCACGAATCAGCTAAATCACGT
ATGGCTGAGCGCAAAGCTAAAATCCGTAACCGAGGCAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5L8

Antitoxin

Source ID Structure
AlphaFold DB U2ZGZ5

References