Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2122732..2123368 Replicon chromosome
Accession NZ_CP026040
Organism Niallia circulans strain PK3_15

Toxin (Protein)


Gene name mazF Uniprot ID R9C9X9
Locus tag C2I17_RS10050 Protein ID WP_016201246.1
Coordinates 2122732..2123082 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0J1I9K1
Locus tag C2I17_RS10055 Protein ID WP_047944180.1
Coordinates 2123087..2123368 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2I17_RS10015 (C2I17_09900) 2118186..2118782 - 597 WP_095331007.1 PP2C family serine/threonine-protein phosphatase -
C2I17_RS10020 (C2I17_09905) 2118779..2119576 - 798 WP_047944172.1 RNA polymerase sigma factor SigB -
C2I17_RS10025 (C2I17_09910) 2119554..2120024 - 471 WP_047944173.1 anti-sigma B factor RsbW -
C2I17_RS10030 (C2I17_09915) 2120021..2120353 - 333 WP_095331009.1 anti-sigma factor antagonist -
C2I17_RS10035 (C2I17_09920) 2120409..2121419 - 1011 WP_047944176.1 PP2C family protein-serine/threonine phosphatase -
C2I17_RS10040 (C2I17_09925) 2121431..2121832 - 402 WP_047944177.1 anti-sigma regulatory factor -
C2I17_RS10045 (C2I17_09930) 2121836..2122201 - 366 WP_047944178.1 STAS domain-containing protein -
C2I17_RS10050 (C2I17_09935) 2122732..2123082 - 351 WP_016201246.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
C2I17_RS10055 (C2I17_09940) 2123087..2123368 - 282 WP_047944180.1 CopG family ribbon-helix-helix protein Antitoxin
C2I17_RS10060 (C2I17_09945) 2123706..2124863 - 1158 WP_249879353.1 alanine racemase -
C2I17_RS10065 (C2I17_09950) 2125016..2126026 - 1011 WP_095331013.1 outer membrane lipoprotein carrier protein LolA -
C2I17_RS10070 (C2I17_09955) 2126345..2126695 - 351 WP_095331015.1 holo-ACP synthase -
C2I17_RS10075 (C2I17_09960) 2126805..2127530 + 726 WP_249879354.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13048.11 Da        Isoelectric Point: 4.9105

>T92890 WP_016201246.1 NZ_CP026040:c2123082-2122732 [Niallia circulans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMEKVDEALQISLGLIEF

Download         Length: 351 bp

>T92890 NZ_CP026040:c2123082-2122732 [Niallia circulans]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAGCAAGGCGGCGTCCGTCCTGT
ACTTGTCATTCAAAACGACATCGGGAATCGGTTCAGTCCCACAGTCATTATTGCAGCAATTACAGCTCAGATTCAAAAGG
CTAAATTGCCGACTCATGTGGAAATTGATGCGAAGCGATATGGTTTTGAAAGAGATTCGGTAATTCTTTTAGAACAAATT
CGTACGATAGATAAACAGAGGCTAACGGACAAAATTACTCATCTTGATGAGGAAATGATGGAAAAAGTCGATGAAGCTCT
ACAAATTAGTTTAGGTCTCATTGAATTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 8.4775

>AT92890 WP_047944180.1 NZ_CP026040:c2123368-2123087 [Niallia circulans]
VSESSTTTEIMIKLPKHLLTELDGFVKQENVNRSEFIYQATKMYLRERKKRHIRESMRRGYMEMAKLNLSIASESFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT92890 NZ_CP026040:c2123368-2123087 [Niallia circulans]
GTGTCTGAATCTAGCACAACGACAGAGATCATGATAAAATTACCAAAGCATTTGTTAACTGAATTGGACGGCTTCGTTAA
GCAAGAAAATGTTAATCGTAGTGAATTTATTTATCAAGCAACGAAAATGTATCTTCGCGAACGGAAAAAGAGACATATCC
GCGAATCGATGAGACGAGGATATATGGAAATGGCTAAATTAAATTTATCCATTGCATCAGAAAGCTTTCTCGCAGAATAC
GAGGCAGAGCATACAGTAGAACGTCTTGTAAGCGGAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9C9X9

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1I9K1

References