Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2217271..2217907 | Replicon | chromosome |
| Accession | NZ_CP026038 | ||
| Organism | Bacillus subtilis PY79 strain PK1_3 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | C2H97_RS11575 | Protein ID | WP_003156187.1 |
| Coordinates | 2217557..2217907 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | C2H97_RS11570 | Protein ID | WP_003225183.1 |
| Coordinates | 2217271..2217552 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2H97_RS11550 (C2H97_11580) | 2213630..2214229 | - | 600 | WP_249848383.1 | rhomboid family intramembrane serine protease | - |
| C2H97_RS11555 (C2H97_11585) | 2214324..2214689 | + | 366 | WP_014475874.1 | holo-ACP synthase | - |
| C2H97_RS11560 (C2H97_11590) | 2214855..2215871 | + | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| C2H97_RS11565 (C2H97_11595) | 2215986..2217155 | + | 1170 | WP_015252766.1 | alanine racemase | - |
| C2H97_RS11570 (C2H97_11600) | 2217271..2217552 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| C2H97_RS11575 (C2H97_11605) | 2217557..2217907 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| C2H97_RS11580 (C2H97_11610) | 2218023..2218847 | + | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| C2H97_RS11585 (C2H97_11615) | 2218852..2219217 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| C2H97_RS11590 (C2H97_11620) | 2219221..2219622 | + | 402 | WP_003225192.1 | serine/threonine-protein kinase RsbT | - |
| C2H97_RS11595 (C2H97_11625) | 2219634..2220641 | + | 1008 | WP_014478900.1 | phosphoserine phosphatase RsbU | - |
| C2H97_RS11600 (C2H97_11630) | 2220710..2221039 | + | 330 | WP_014475877.1 | anti-sigma factor antagonist RsbV | - |
| C2H97_RS11605 (C2H97_11635) | 2221036..2221518 | + | 483 | WP_021481702.1 | anti-sigma B factor RsbW | - |
| C2H97_RS11610 (C2H97_11640) | 2221484..2222272 | + | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| C2H97_RS11615 (C2H97_11645) | 2222272..2222871 | + | 600 | WP_120027794.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T92886 WP_003156187.1 NZ_CP026038:2217557-2217907 [Bacillus subtilis PY79]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T92886 NZ_CP026038:2217557-2217907 [Bacillus subtilis PY79]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT92886 WP_003225183.1 NZ_CP026038:2217271-2217552 [Bacillus subtilis PY79]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT92886 NZ_CP026038:2217271-2217552 [Bacillus subtilis PY79]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|