Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1126206..1126842 | Replicon | chromosome |
| Accession | NZ_CP026037 | ||
| Organism | Bacillus subtilis strain PK5_17 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | C2H95_RS05750 | Protein ID | WP_003156187.1 |
| Coordinates | 1126492..1126842 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | C2H95_RS05745 | Protein ID | WP_003225183.1 |
| Coordinates | 1126206..1126487 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2H95_RS05725 (C2H95_05710) | 1122565..1123164 | - | 600 | WP_249848383.1 | rhomboid family intramembrane serine protease | - |
| C2H95_RS05730 (C2H95_05715) | 1123259..1123624 | + | 366 | WP_014475874.1 | holo-ACP synthase | - |
| C2H95_RS05735 (C2H95_05720) | 1123790..1124806 | + | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| C2H95_RS05740 (C2H95_05725) | 1124921..1126090 | + | 1170 | WP_015252766.1 | alanine racemase | - |
| C2H95_RS05745 (C2H95_05730) | 1126206..1126487 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| C2H95_RS05750 (C2H95_05735) | 1126492..1126842 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| C2H95_RS05755 (C2H95_05740) | 1126958..1127782 | + | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| C2H95_RS05760 (C2H95_05745) | 1127787..1128152 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| C2H95_RS05765 (C2H95_05750) | 1128156..1128557 | + | 402 | WP_003225192.1 | serine/threonine-protein kinase RsbT | - |
| C2H95_RS05770 (C2H95_05755) | 1128569..1129576 | + | 1008 | WP_014478900.1 | phosphoserine phosphatase RsbU | - |
| C2H95_RS05775 (C2H95_05760) | 1129645..1129974 | + | 330 | WP_014475877.1 | anti-sigma factor antagonist RsbV | - |
| C2H95_RS05780 (C2H95_05765) | 1129971..1130453 | + | 483 | WP_021481702.1 | anti-sigma B factor RsbW | - |
| C2H95_RS05785 (C2H95_05770) | 1130419..1131207 | + | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| C2H95_RS05790 (C2H95_05775) | 1131207..1131806 | + | 600 | WP_021481701.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T92884 WP_003156187.1 NZ_CP026037:1126492-1126842 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T92884 NZ_CP026037:1126492-1126842 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT92884 WP_003225183.1 NZ_CP026037:1126206-1126487 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT92884 NZ_CP026037:1126206-1126487 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|