Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1724816..1725452 | Replicon | chromosome |
| Accession | NZ_CP026035 | ||
| Organism | Bacillus subtilis strain PK5_68 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | C2H96_RS08735 | Protein ID | WP_003156187.1 |
| Coordinates | 1724816..1725166 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | C2H96_RS08740 | Protein ID | WP_003225183.1 |
| Coordinates | 1725171..1725452 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2H96_RS08695 (C2H96_08620) | 1719852..1720451 | - | 600 | WP_120027794.1 | phosphoserine phosphatase RsbX | - |
| C2H96_RS08700 (C2H96_08625) | 1720451..1721239 | - | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| C2H96_RS08705 (C2H96_08630) | 1721205..1721687 | - | 483 | WP_021481702.1 | anti-sigma B factor RsbW | - |
| C2H96_RS08710 (C2H96_08635) | 1721684..1722013 | - | 330 | WP_014475877.1 | anti-sigma factor antagonist RsbV | - |
| C2H96_RS08715 (C2H96_08640) | 1722082..1723089 | - | 1008 | WP_014478900.1 | phosphoserine phosphatase RsbU | - |
| C2H96_RS08720 (C2H96_08645) | 1723101..1723502 | - | 402 | WP_003225192.1 | serine/threonine-protein kinase RsbT | - |
| C2H96_RS08725 (C2H96_08650) | 1723506..1723871 | - | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| C2H96_RS08730 (C2H96_08655) | 1723876..1724700 | - | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| C2H96_RS08735 (C2H96_08660) | 1724816..1725166 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| C2H96_RS08740 (C2H96_08665) | 1725171..1725452 | - | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| C2H96_RS08745 (C2H96_08670) | 1725568..1726737 | - | 1170 | WP_015252766.1 | alanine racemase | - |
| C2H96_RS08750 (C2H96_08675) | 1726852..1727868 | - | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| C2H96_RS08755 (C2H96_08680) | 1728034..1728399 | - | 366 | WP_014475874.1 | holo-ACP synthase | - |
| C2H96_RS08760 (C2H96_08685) | 1728494..1729093 | + | 600 | WP_249848383.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T92881 WP_003156187.1 NZ_CP026035:c1725166-1724816 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T92881 NZ_CP026035:c1725166-1724816 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT92881 WP_003225183.1 NZ_CP026035:c1725452-1725171 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT92881 NZ_CP026035:c1725452-1725171 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|