Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2467856..2468492 | Replicon | chromosome |
| Accession | NZ_CP026034 | ||
| Organism | Bacillus subtilis strain PK5_52 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | C2H94_RS12970 | Protein ID | WP_003156187.1 |
| Coordinates | 2468142..2468492 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | C2H94_RS12965 | Protein ID | WP_003225183.1 |
| Coordinates | 2467856..2468137 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2H94_RS12945 (C2H94_12890) | 2464215..2464814 | - | 600 | WP_249848383.1 | rhomboid family intramembrane serine protease | - |
| C2H94_RS12950 (C2H94_12895) | 2464909..2465274 | + | 366 | WP_014475874.1 | holo-ACP synthase | - |
| C2H94_RS12955 (C2H94_12900) | 2465440..2466456 | + | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| C2H94_RS12960 (C2H94_12905) | 2466571..2467740 | + | 1170 | WP_015252766.1 | alanine racemase | - |
| C2H94_RS12965 (C2H94_12910) | 2467856..2468137 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| C2H94_RS12970 (C2H94_12915) | 2468142..2468492 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| C2H94_RS12975 (C2H94_12920) | 2468608..2469432 | + | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| C2H94_RS12980 (C2H94_12925) | 2469437..2469802 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| C2H94_RS12985 (C2H94_12930) | 2469806..2470207 | + | 402 | WP_003225192.1 | serine/threonine-protein kinase RsbT | - |
| C2H94_RS12990 (C2H94_12935) | 2470219..2471226 | + | 1008 | WP_014478900.1 | phosphoserine phosphatase RsbU | - |
| C2H94_RS12995 (C2H94_12940) | 2471295..2471624 | + | 330 | WP_014475877.1 | anti-sigma factor antagonist RsbV | - |
| C2H94_RS13000 (C2H94_12945) | 2471621..2472103 | + | 483 | WP_021481702.1 | anti-sigma B factor RsbW | - |
| C2H94_RS13005 (C2H94_12950) | 2472069..2472857 | + | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| C2H94_RS13010 (C2H94_12955) | 2472857..2473456 | + | 600 | WP_021481701.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T92878 WP_003156187.1 NZ_CP026034:2468142-2468492 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T92878 NZ_CP026034:2468142-2468492 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT92878 WP_003225183.1 NZ_CP026034:2467856-2468137 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT92878 NZ_CP026034:2467856-2468137 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|