Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1544944..1545580 | Replicon | chromosome |
| Accession | NZ_CP026030 | ||
| Organism | Bacillus subtilis strain PK3_9 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | C2H91_RS07555 | Protein ID | WP_003156187.1 |
| Coordinates | 1544944..1545294 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | C2H91_RS07560 | Protein ID | WP_003225183.1 |
| Coordinates | 1545299..1545580 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C2H91_RS07515 (C2H91_07510) | 1539980..1540579 | - | 600 | WP_021481701.1 | phosphoserine phosphatase RsbX | - |
| C2H91_RS07520 (C2H91_07515) | 1540579..1541367 | - | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| C2H91_RS07525 (C2H91_07520) | 1541333..1541815 | - | 483 | WP_021481702.1 | anti-sigma B factor RsbW | - |
| C2H91_RS07530 (C2H91_07525) | 1541812..1542141 | - | 330 | WP_014475877.1 | anti-sigma factor antagonist RsbV | - |
| C2H91_RS07535 (C2H91_07530) | 1542210..1543217 | - | 1008 | WP_014478900.1 | phosphoserine phosphatase RsbU | - |
| C2H91_RS07540 (C2H91_07535) | 1543229..1543630 | - | 402 | WP_003225192.1 | serine/threonine-protein kinase RsbT | - |
| C2H91_RS07545 (C2H91_07540) | 1543634..1543999 | - | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| C2H91_RS07550 (C2H91_07545) | 1544004..1544828 | - | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| C2H91_RS07555 (C2H91_07550) | 1544944..1545294 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| C2H91_RS07560 (C2H91_07555) | 1545299..1545580 | - | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| C2H91_RS07565 (C2H91_07560) | 1545696..1546865 | - | 1170 | WP_015252766.1 | alanine racemase | - |
| C2H91_RS07570 (C2H91_07565) | 1546980..1547996 | - | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| C2H91_RS07575 (C2H91_07570) | 1548162..1548527 | - | 366 | WP_015252768.1 | holo-ACP synthase | - |
| C2H91_RS07580 (C2H91_07575) | 1548622..1549221 | + | 600 | WP_041850724.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T92875 WP_003156187.1 NZ_CP026030:c1545294-1544944 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T92875 NZ_CP026030:c1545294-1544944 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT92875 WP_003225183.1 NZ_CP026030:c1545580-1545299 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT92875 NZ_CP026030:c1545580-1545299 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|