92873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3967661..3968296 Replicon chromosome
Accession NZ_CP026029
Organism Paenibacillus sp. PK3_47

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C2I18_RS17635 Protein ID WP_249897062.1
Coordinates 3967946..3968296 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C2I18_RS17630 Protein ID WP_275100992.1
Coordinates 3967661..3967942 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2I18_RS17605 (C2I18_17555) 3963068..3963256 - 189 WP_249897057.1 hypothetical protein -
C2I18_RS17610 (C2I18_17560) 3963887..3964276 + 390 WP_249897058.1 hypothetical protein -
C2I18_RS17615 3964444..3964935 - 492 WP_249897059.1 hypothetical protein -
C2I18_RS17620 (C2I18_17565) 3964958..3966043 + 1086 WP_249897060.1 outer membrane lipoprotein-sorting protein -
C2I18_RS17625 (C2I18_17570) 3966268..3967449 + 1182 WP_249897061.1 alanine racemase -
C2I18_RS17630 (C2I18_17575) 3967661..3967942 + 282 WP_275100992.1 ribbon-helix-helix protein, CopG family Antitoxin
C2I18_RS17635 (C2I18_17580) 3967946..3968296 + 351 WP_249897062.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C2I18_RS17640 (C2I18_17585) 3968408..3969061 + 654 WP_249897063.1 TetR/AcrR family transcriptional regulator -
C2I18_RS17645 (C2I18_17590) 3969271..3970476 + 1206 WP_249897064.1 MFS transporter -
C2I18_RS17650 (C2I18_17595) 3970675..3972873 + 2199 WP_249902154.1 Tex family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12780.68 Da        Isoelectric Point: 5.1171

>T92873 WP_249897062.1 NZ_CP026029:3967946-3968296 [Paenibacillus sp. PK3_47]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDDTMKKVDESLQISLGLIDF

Download         Length: 351 bp

>T92873 NZ_CP026029:3967946-3968296 [Paenibacillus sp. PK3_47]
TTGATTGTTAAACGCGGCGACGTTTTTTTTGCCGACCTTTCACCTGTGGTAGGTTCAGAGCAAGGCGGGGTAAGGCCGGT
ACTGGTCATACAGAACGACATCGGCAATCGCTTCAGCCCGACGGTTATTGTGGCAGCCATTACTGCCCAGATCCAGAAGG
CCAAATTGCCGACGCATGTGGAGATTGATGCGGCATCCCACGGCTTTGACCGGGATTCAGTCATTCTCCTGGAGCAGGTT
CGGACAATTGACAAACAACGCTTAACCGATAAGATCACCCATCTTGACGATGATACAATGAAAAAGGTGGATGAATCGCT
GCAAATCAGTCTCGGCCTGATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10674.40 Da        Isoelectric Point: 6.9810

>AT92873 WP_275100992.1 NZ_CP026029:3967661-3967942 [Paenibacillus sp. PK3_47]
MANLQNTKRIMISLPDHLLQEVDGIAQLENSNRSELIRQAMKLYLSERRKRMIRESMQRGYMEMAKINLTMACEAFLAEE
DADSTLGRLVSGV

Download         Length: 282 bp

>AT92873 NZ_CP026029:3967661-3967942 [Paenibacillus sp. PK3_47]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCCGATCATCTCTTGCAGGAAGTAGATGGAATCGCTCA
ATTGGAGAACTCCAACCGGAGTGAATTGATTAGGCAGGCCATGAAGCTGTATTTAAGCGAACGGAGGAAACGTATGATCC
GGGAGTCGATGCAGCGGGGATACATGGAGATGGCCAAAATCAATTTGACCATGGCATGCGAGGCTTTTCTCGCTGAGGAA
GATGCAGACAGTACTCTTGGCCGCTTAGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References