92747

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4887095..4887611 Replicon chromosome
Accession NZ_CP026023
Organism Klebsiella pneumoniae strain 11420

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag C2D59_RS23220 Protein ID WP_004894697.1
Coordinates 4887095..4887379 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2D59_RS23225 Protein ID WP_002886901.1
Coordinates 4887369..4887611 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2D59_RS23200 4882490..4882798 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
C2D59_RS28070 4882883..4883056 + 174 WP_002886906.1 hypothetical protein -
C2D59_RS23205 4883059..4883802 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
C2D59_RS23210 4884160..4886298 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
C2D59_RS23215 4886627..4887091 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2D59_RS23220 4887095..4887379 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2D59_RS23225 4887369..4887611 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2D59_RS23230 4887689..4889598 - 1910 Protein_4625 BglG family transcription antiterminator -
C2D59_RS23235 4889621..4890775 - 1155 WP_153244942.1 lactonase family protein -
C2D59_RS23240 4890842..4891582 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T92747 WP_004894697.1 NZ_CP026023:c4887379-4887095 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T92747 NZ_CP026023:c4887379-4887095 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT92747 WP_002886901.1 NZ_CP026023:c4887611-4887369 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT92747 NZ_CP026023:c4887611-4887369 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References