Detailed information of TA system TA092746

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4807856..4808559
• Replicon: chromosome
• Accession: NZ_CP026023
• Organism: Klebsiella pneumoniae strain 11420

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: C2D59_RS22860
• Protein ID: WP_017880111.1
• Coordinates: 4807856..4808197 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: C2D59_RS22865
• Protein ID: WP_050131139.1
• Coordinates: 4808218..4808559 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2D59_RS22835	4804427..4805554	+	1128	WP_023325431.1	PAAR domain-containing protein	-
C2D59_RS22840	4805544..4805807	+	264	WP_004192273.1	hypothetical protein	-
C2D59_RS22845	4805953..4806087	+	135	Protein_4551	transposase	-
C2D59_RS22850	4806100..4806210	-	111	Protein_4552	DUF4102 domain-containing protein	-
C2D59_RS22855	4806585..4807592	-	1008	WP_017880110.1	restriction endonuclease	-
C2D59_RS22860	4807856..4808197	-	342	WP_017880111.1	TA system toxin CbtA family protein	Toxin
C2D59_RS22865	4808218..4808559	-	342	WP_050131139.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C2D59_RS22870	4808570..4809112	-	543	WP_017880113.1	DNA repair protein RadC	-
C2D59_RS22875	4809125..4809568	-	444	WP_017880114.1	antirestriction protein	-
C2D59_RS22880	4809599..4810420	-	822	WP_017880115.1	DUF945 domain-containing protein	-
C2D59_RS22885	4810541..4811014	-	474	WP_031280324.1	hypothetical protein	-
C2D59_RS22890	4811086..4811538	-	453	WP_031280325.1	hypothetical protein	-
C2D59_RS22895	4811574..4812290	-	717	WP_032417794.1	WYL domain-containing protein	-
C2D59_RS22900	4812534..4813409	-	876	WP_017880120.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4800300..4835066	34766

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12811.73 Da
• Isoelectric Point: 8.4941

>T92746 WP_017880111.1 NZ_CP026023:c4808197-4807856 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T92746 NZ_CP026023:c4808197-4807856 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGACGCTATATCTGTCGCCTGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACTCTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTATGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12821.45 Da
• Isoelectric Point: 6.3148

>AT92746 WP_050131139.1 NZ_CP026023:c4808559-4808218 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT92746 NZ_CP026023:c4808559-4808218 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTTTAAAATGGGGACTGAATTGTAATATGACACCTTGCTTTGGTGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGATCGGGCCTGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCACACGTTTTATCCGCCAAATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACAGTGTCACCCTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA