Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 138550..139220 Replicon plasmid p11492-CTXM
Accession NZ_CP026022
Organism Klebsiella pneumoniae strain 11492

Toxin (Protein)


Gene name vagD Uniprot ID Q6U619
Locus tag C2D60_RS26620 Protein ID WP_004213072.1
Coordinates 138777..139220 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q6U620
Locus tag C2D60_RS26615 Protein ID WP_004213073.1
Coordinates 138550..138780 (+) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2D60_RS26590 134773..135672 - 900 WP_004225022.1 nucleotide-binding protein -
C2D60_RS26595 135662..135952 - 291 WP_004213078.1 hypothetical protein -
C2D60_RS26600 136304..136510 + 207 WP_004213077.1 hypothetical protein -
C2D60_RS26605 136500..136793 - 294 WP_004213076.1 hypothetical protein -
C2D60_RS26610 136809..137942 - 1134 WP_004213075.1 DUF3800 domain-containing protein -
C2D60_RS26615 138550..138780 + 231 WP_004213073.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C2D60_RS26620 138777..139220 + 444 WP_004213072.1 type II toxin-antitoxin system VapC family toxin Toxin
C2D60_RS26625 139234..139650 - 417 Protein_139 restriction endonuclease -
C2D60_RS26630 139654..139947 - 294 Protein_140 transposase -
C2D60_RS27870 140365..141002 + 638 Protein_141 response regulator -
C2D60_RS26645 141518..141924 - 407 Protein_142 GAF domain-containing protein -
C2D60_RS26655 142015..142935 - 921 WP_004213934.1 DUF1471 domain-containing protein -
C2D60_RS26660 142984..143475 - 492 WP_011251327.1 DM13 domain-containing protein -
C2D60_RS26665 143538..143813 - 276 WP_004213932.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-14 rmpA / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB 1..193176 193176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 148 a.a.        Molecular weight: 16006.74 Da        Isoelectric Point: 9.3642

>T92731 WP_004213072.1 NZ_CP026022:138777-139220 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS

Download         Length: 444 bp

>T92731 NZ_CP026022:138777-139220 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT92731 WP_004213073.1 NZ_CP026022:138550-138780 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT92731 NZ_CP026022:138550-138780 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q6U619


Antitoxin

Source ID Structure
AlphaFold DB Q6U620

References