Detailed information of TA system TA092690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4946028..4946544
• Replicon: chromosome
• Accession: NZ_CP026013
• Organism: Klebsiella variicola strain 13450

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C2D62_RS23730
• Protein ID: WP_022065401.1
• Coordinates: 4946028..4946312 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: C2D62_RS23735
• Protein ID: WP_002886901.1
• Coordinates: 4946302..4946544 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2D62_RS23715	4941131..4942786	+	1656	WP_008807132.1	alpha,alpha-phosphotrehalase	-
C2D62_RS23720	4943172..4945310	+	2139	WP_012543083.1	anaerobic ribonucleoside-triphosphate reductase	-
C2D62_RS23725	4945560..4946024	+	465	WP_022065402.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
C2D62_RS23730	4946028..4946312	-	285	WP_022065401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C2D62_RS23735	4946302..4946544	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C2D62_RS23740	4946622..4948532	-	1911	WP_032731805.1	BglG family transcription antiterminator	-
C2D62_RS23745	4948555..4949709	-	1155	WP_022065399.1	lactonase family protein	-
C2D62_RS23750	4949835..4950575	-	741	WP_022065398.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11128.97 Da
• Isoelectric Point: 10.2849

>T92690 WP_022065401.1 NZ_CP026013:c4946312-4946028 [Klebsiella variicola]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T92690 NZ_CP026013:c4946312-4946028 [Klebsiella variicola]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGATGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT92690 WP_002886901.1 NZ_CP026013:c4946544-4946302 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT92690 NZ_CP026013:c4946544-4946302 [Klebsiella variicola]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0