Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4817898..4818474 Replicon chromosome
Accession NZ_CP026013
Organism Klebsiella variicola strain 13450

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag C2D62_RS23160 Protein ID WP_012542979.1
Coordinates 4818187..4818474 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag C2D62_RS23155 Protein ID WP_022065028.1
Coordinates 4817898..4818200 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2D62_RS23130 4813307..4814371 - 1065 WP_008807596.1 DUF2955 domain-containing protein -
C2D62_RS23135 4814361..4815428 - 1068 WP_022065029.1 HlyD family secretion protein -
C2D62_RS23140 4815435..4815899 - 465 WP_008807598.1 MarR family transcriptional regulator -
C2D62_RS23145 4816065..4816229 - 165 WP_008807599.1 DUF1127 domain-containing protein -
C2D62_RS23150 4816407..4817819 + 1413 WP_008807600.1 PLP-dependent aminotransferase family protein -
C2D62_RS23155 4817898..4818200 - 303 WP_022065028.1 BrnA antitoxin family protein Antitoxin
C2D62_RS23160 4818187..4818474 - 288 WP_012542979.1 BrnT family toxin Toxin
C2D62_RS23165 4818642..4819061 - 420 WP_048271457.1 FosA family fosfomycin resistance glutathione transferase -
C2D62_RS23170 4819055..4819963 - 909 WP_016160219.1 LysR family transcriptional regulator -
C2D62_RS23175 4820050..4820832 + 783 WP_012542981.1 NAD(P)H-dependent oxidoreductase -
C2D62_RS23180 4820974..4821558 + 585 WP_022065974.1 TetR/AcrR family transcriptional regulator -
C2D62_RS23185 4821580..4822383 + 804 WP_022065975.1 winged helix-turn-helix domain-containing protein -
C2D62_RS23190 4822380..4822898 + 519 WP_004182811.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11245.77 Da        Isoelectric Point: 8.6574

>T92689 WP_012542979.1 NZ_CP026013:c4818474-4818187 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T92689 NZ_CP026013:c4818474-4818187 [Klebsiella variicola]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCATTAAGTAATCTACGAAAACATGGAGTCCGGTTTGAAGAAGCGGT
ATTAGTCTTTGACGATCCGCGGCACCTTTCCCGCCAGGAGCGGTTTGAGAATGGTGAATATCGCTGGCAGACCATCGGTC
TTGTGCATGGGATCCTTGTTATCCTGGTGGCGCATTCGGTCCGTTTTGAAAGTGGAACTGAGGTTATTCGTATTATCAGC
GCCCGGAAGGCGGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11320.98 Da        Isoelectric Point: 10.3129

>AT92689 WP_022065028.1 NZ_CP026013:c4818200-4817898 [Klebsiella variicola]
MSMVKHKRGNTAALTAKRDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp

>AT92689 NZ_CP026013:c4818200-4817898 [Klebsiella variicola]
ATGAGCATGGTTAAACATAAACGCGGCAATACGGCGGCGCTTACCGCTAAGCGTGATGCCGAACTCAAAGCGCTAGCGAG
CAAAGCCGATGAGGATATCGATTACAGCGATATCCCCGCTACAGACGATGCGCAATGGTCAGATGCCGTTCGCGGCAAAT
TTTTTCGACCGCTAAAAACACAGGCTTCTGTGCGCATTGATGCCGATGTCATGGAGTGGCTCAAACGTCCAGGAAAAGGC
TATCAAACTCGACTGAATGCGATTTTAAGAGAAGCGATGATTCGCGATCTTAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References