Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 276536..277167 Replicon chromosome
Accession NZ_CP026013
Organism Klebsiella variicola strain 13450

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C2D62_RS01255 Protein ID WP_022066423.1
Coordinates 276536..276811 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C2D62_RS01260 Protein ID WP_022066422.1
Coordinates 276808..277167 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2D62_RS01235 271772..272107 + 336 WP_002921203.1 universal stress protein UspB -
C2D62_RS01240 272167..273663 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
C2D62_RS01245 273893..275086 + 1194 WP_012967106.1 NAD(P)/FAD-dependent oxidoreductase -
C2D62_RS01250 275126..276139 - 1014 WP_022066424.1 magnesium transporter -
C2D62_RS01255 276536..276811 + 276 WP_022066423.1 type II toxin-antitoxin system HicA family toxin Toxin
C2D62_RS01260 276808..277167 + 360 WP_022066422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2D62_RS01265 277195..277596 - 402 WP_022066421.1 nickel-responsive transcriptional regulator NikR -
C2D62_RS01270 277584..278375 - 792 WP_012540373.1 nickel import ATP-binding protein NikE -
C2D62_RS01275 278372..279136 - 765 WP_048272087.1 nickel import ATP-binding protein NikD -
C2D62_RS01280 279136..279969 - 834 WP_048272086.1 nickel ABC transporter permease subunit NikC -
C2D62_RS01285 279966..280910 - 945 WP_022066418.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10267.85 Da        Isoelectric Point: 10.3165

>T92673 WP_022066423.1 NZ_CP026013:276536-276811 [Klebsiella variicola]
MEQQVLSLRNKQRHTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T92673 NZ_CP026013:276536-276811 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGTTGGAGCAACTGTTTAAAACCCCTGTCCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATCAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13294.99 Da        Isoelectric Point: 4.4605

>AT92673 WP_022066422.1 NZ_CP026013:276808-277167 [Klebsiella variicola]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT92673 NZ_CP026013:276808-277167 [Klebsiella variicola]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGGCAACCCGCCGTTATCAACTACGTGCCTGAGCTCAATGC
ATTCCGTGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGCTGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCGGAGGAACAGGTTTCCGTAAACACCTG
GATCCTCGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References