Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4700850..4701366 Replicon chromosome
Accession NZ_CP026011
Organism Klebsiella pneumoniae strain K2044

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag C2D63_RS22285 Protein ID WP_004178374.1
Coordinates 4700850..4701134 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C2D63_RS22290 Protein ID WP_002886901.1
Coordinates 4701124..4701366 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2D63_RS22265 4696246..4696554 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
C2D63_RS26525 4696639..4696812 + 174 WP_041169004.1 hypothetical protein -
C2D63_RS22270 4696815..4697558 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C2D63_RS22275 4697915..4700053 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C2D63_RS22280 4700382..4700846 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C2D63_RS22285 4700850..4701134 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2D63_RS22290 4701124..4701366 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2D63_RS22295 4701444..4703354 - 1911 WP_012737231.1 BglG family transcription antiterminator -
C2D63_RS22300 4703377..4704531 - 1155 WP_012737230.1 lactonase family protein -
C2D63_RS22305 4704598..4705338 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T92668 WP_004178374.1 NZ_CP026011:c4701134-4700850 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T92668 NZ_CP026011:c4701134-4700850 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT92668 WP_002886901.1 NZ_CP026011:c4701366-4701124 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT92668 NZ_CP026011:c4701366-4701124 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References