Detailed information of TA system TA092646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1658406..1659051
• Replicon: chromosome
• Accession: NZ_CP026009
• Organism: Actinobacillus pleuropneumoniae strain App6

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: CYK57_RS07650
• Protein ID: WP_005619674.1
• Coordinates: 1658680..1659051 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: CYK57_RS07645
• Protein ID: WP_005598477.1
• Coordinates: 1658406..1658699 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYK57_RS07615	1653738..1654421	-	684	WP_005605188.1	arginine ABC transporter permease ArtM	-
CYK57_RS07620	1654421..1655092	-	672	WP_011848573.1	arginine ABC transporter permease ArtQ	-
CYK57_RS07625	1655098..1655832	-	735	WP_009874916.1	transporter substrate-binding domain-containing protein	-
CYK57_RS07630	1655837..1656571	-	735	WP_207618123.1	arginine ABC transporter ATP-binding protein ArtP	-
CYK57_RS07635	1656796..1657293	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
CYK57_RS07640	1657366..1658328	+	963	WP_005619672.1	calcium/sodium antiporter	-
CYK57_RS07645	1658406..1658699	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
CYK57_RS07650	1658680..1659051	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CYK57_RS07655	1659245..1660996	+	1752	WP_005601957.1	protein-disulfide reductase DsbD	-
CYK57_RS07660	1661054..1661623	+	570	WP_005601959.1	elongation factor P hydroxylase	-
CYK57_RS07665	1661667..1662521	-	855	WP_009874917.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T92646 WP_005619674.1 NZ_CP026009:c1659051-1658680 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T92646 NZ_CP026009:c1659051-1658680 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT92646 WP_005598477.1 NZ_CP026009:c1658699-1658406 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT92646 NZ_CP026009:c1658699-1658406 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206