Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 77056..78778 Replicon chromosome
Accession NZ_CP026009
Organism Actinobacillus pleuropneumoniae strain App6

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag CYK57_RS00340 Protein ID WP_099821823.1
Coordinates 77056..77994 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag CYK57_RS00345 Protein ID WP_099821822.1
Coordinates 77987..78778 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYK57_RS00320 72997..73509 - 513 WP_172436295.1 S26 family signal peptidase -
CYK57_RS00325 73493..73840 - 348 WP_004249366.1 hypothetical protein -
CYK57_RS00330 73833..76232 - 2400 WP_099821793.1 type IV secretion system protein TraC -
CYK57_RS00335 76232..76924 - 693 WP_024008832.1 DsbC family protein -
CYK57_RS00340 77056..77994 - 939 WP_099821823.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CYK57_RS00345 77987..78778 - 792 WP_099821822.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
CYK57_RS00350 78999..79385 - 387 WP_000180225.1 hypothetical protein -
CYK57_RS00355 79382..79954 - 573 WP_024008834.1 type IV conjugative transfer system lipoprotein TraV -
CYK57_RS00360 80029..81318 - 1290 WP_099821792.1 TraB/VirB10 family protein -
CYK57_RS00365 81321..82217 - 897 WP_099821791.1 type-F conjugative transfer system secretin TraK -
CYK57_RS00370 82201..82827 - 627 WP_000667170.1 hypothetical protein -
CYK57_RS00375 82824..83105 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
CYK57_RS00380 83394..83588 + 195 Protein_75 plasmid-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-272)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-97)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35506.74 Da        Isoelectric Point: 4.8978

>T92643 WP_099821823.1 NZ_CP026009:c77994-77056 [Actinobacillus pleuropneumoniae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T92643 NZ_CP026009:c77994-77056 [Actinobacillus pleuropneumoniae]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGAAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCGCTGAATGAGAAATTTCAGGCAGAAT
TTGATGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCTTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATTATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATAAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30110.48 Da        Isoelectric Point: 9.3513

>AT92643 WP_099821822.1 NZ_CP026009:c78778-77987 [Actinobacillus pleuropneumoniae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHDG

Download         Length: 792 bp

>AT92643 NZ_CP026009:c78778-77987 [Actinobacillus pleuropneumoniae]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATGATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References