92642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1984702..1985338 Replicon chromosome
Accession NZ_CP026008
Organism Bacillus aerophilus strain 232

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag BAE_RS10160 Protein ID WP_003214169.1
Coordinates 1984988..1985338 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag BAE_RS10155 Protein ID WP_003214273.1
Coordinates 1984702..1984983 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAE_RS10135 1980856..1981461 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
BAE_RS10140 1981556..1981921 + 366 WP_017358398.1 holo-ACP synthase -
BAE_RS10145 1982082..1983098 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
BAE_RS10150 1983227..1984408 + 1182 WP_108611670.1 alanine racemase -
BAE_RS10155 1984702..1984983 + 282 WP_003214273.1 hypothetical protein Antitoxin
BAE_RS10160 1984988..1985338 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BAE_RS10165 1985453..1986283 + 831 WP_058336383.1 STAS domain-containing protein -
BAE_RS10170 1986288..1986656 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
BAE_RS10175 1986659..1987060 + 402 WP_003214085.1 anti-sigma regulatory factor -
BAE_RS10180 1987071..1988078 + 1008 WP_129548106.1 PP2C family protein-serine/threonine phosphatase -
BAE_RS10185 1988138..1988467 + 330 WP_007496474.1 anti-sigma factor antagonist -
BAE_RS10190 1988464..1988952 + 489 WP_129548107.1 anti-sigma B factor RsbW -
BAE_RS10195 1988918..1989706 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
BAE_RS10200 1989706..1990305 + 600 WP_008346897.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T92642 WP_003214169.1 NZ_CP026008:1984988-1985338 [Bacillus aerophilus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T92642 NZ_CP026008:1984988-1985338 [Bacillus aerophilus]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAAATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT92642 WP_003214273.1 NZ_CP026008:1984702-1984983 [Bacillus aerophilus]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT92642 NZ_CP026008:1984702-1984983 [Bacillus aerophilus]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References