Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2236569..2237158 Replicon chromosome
Accession NZ_CP025985
Organism Ralstonia solanacearum strain RSCM

Toxin (Protein)


Gene name hicA Uniprot ID A0A1U9VH68
Locus tag CYD94_RS10315 Protein ID WP_072633588.1
Coordinates 2236569..2236823 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1U9VFS6
Locus tag CYD94_RS10320 Protein ID WP_028853154.1
Coordinates 2236820..2237158 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYD94_RS10295 2231810..2232301 - 492 WP_011001641.1 glycoside hydrolase family protein -
CYD94_RS10300 2232370..2233026 - 657 WP_072633591.1 hypothetical protein -
CYD94_RS10310 2233363..2236518 - 3156 WP_103025728.1 host specificity protein J -
CYD94_RS10315 2236569..2236823 + 255 WP_072633588.1 type II toxin-antitoxin system HicA family toxin Toxin
CYD94_RS10320 2236820..2237158 + 339 WP_028853154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CYD94_RS10325 2237228..2237830 - 603 WP_072633645.1 tail assembly protein -
CYD94_RS10330 2237834..2238544 - 711 WP_072633587.1 C40 family peptidase -
CYD94_RS10335 2238546..2239247 - 702 WP_103025729.1 phage minor tail protein L -
CYD94_RS10340 2239244..2239840 - 597 WP_103025730.1 tail fiber assembly protein -
CYD94_RS10345 2239846..2240523 - 678 WP_103025731.1 phage tail protein -
CYD94_RS10350 2240520..2240858 - 339 WP_103025732.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2226119..2267934 41815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T92632 WP_072633588.1 NZ_CP025985:2236569-2236823 [Ralstonia solanacearum]
MKAKHQKTLELIFSRPTPAGVKWADAVTLMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T92632 NZ_CP025985:2236569-2236823 [Ralstonia solanacearum]
ATGAAAGCCAAACACCAGAAGACGCTGGAGCTGATCTTTTCCCGCCCTACGCCAGCGGGCGTTAAGTGGGCCGATGCCGT
CACGCTCATGCGAGAACTGGGCGCGGAATTGGAGGAGCGCGAGGGTTCTCGCGTGGCCGTCTTCCTGTTTGGTCAAGTCA
AAGTGATGCATCGACCACACCCATCTCCCGATATGGACAAGGGCGCTGTGGCCTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11968.58 Da        Isoelectric Point: 5.1375

>AT92632 WP_028853154.1 NZ_CP025985:2236820-2237158 [Ralstonia solanacearum]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp

>AT92632 NZ_CP025985:2236820-2237158 [Ralstonia solanacearum]
ATGATCAACGTCATGAACATCGGCGGCCACAAGGCCGTCATCGCCTACGACCCGGATATCGAAATGTTCCGTGGCGAGTT
TGTTGGCCTGAACGGTGGCGCCGATTTCTACGCCGCCGATGTGACCGGCCTGCACCGCGAAGGTGAGTTGTCGCTGCGCG
TGTTTCTGGAAGAGTGCGCACGGCGTGGCGTTGAGCCGCAAAAGCACTTTTCCGGCAAGTTCGTGCTGCGCGTGGAGGGC
AAGGTGCACGAGGCCGCCGCCATCGCCGCTGCCGCGCAAGGCGTGAGCCTTAACCAGTGGGCAGCCGGCGTGCTGGAGCA
AGCCGCCGAGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VH68

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VFS6

References