Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 24797..25554 Replicon plasmid pEM76
Accession NZ_CP025981
Organism Escherichia marmotae strain HT073016

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag C1192_RS24740 Protein ID WP_038354869.1
Coordinates 25069..25554 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag C1192_RS24735 Protein ID WP_101958039.1
Coordinates 24797..25081 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1192_RS24710 19874..20821 - 948 WP_038355997.1 tyrosine-type recombinase/integrase -
C1192_RS24720 21324..22001 + 678 WP_103194845.1 IS66-like element accessory protein TnpA -
C1192_RS24725 22001..22348 + 348 WP_069906977.1 IS66 family insertion sequence element accessory protein TnpB -
C1192_RS24730 22368..23939 + 1572 WP_103194837.1 IS66 family transposase -
C1192_RS24735 24797..25081 + 285 WP_101958039.1 DUF1778 domain-containing protein Antitoxin
C1192_RS24740 25069..25554 + 486 WP_038354869.1 GNAT family N-acetyltransferase Toxin
C1192_RS24745 25682..26974 - 1293 WP_103194846.1 IS4 family transposase -
C1192_RS24750 27059..27187 + 129 Protein_23 transposase -
C1192_RS24755 27213..28784 - 1572 WP_103194767.1 IS66 family transposase -
C1192_RS24760 28804..29151 - 348 WP_069906977.1 IS66 family insertion sequence element accessory protein TnpB -
C1192_RS24765 29151..29828 - 678 WP_001339397.1 IS66 family insertion sequence hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ipaH9.8 / ospC4 1..76160 76160
- inside IScluster/Tn - - 16327..31379 15052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-151)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17616.42 Da        Isoelectric Point: 9.8926

>T92629 WP_038354869.1 NZ_CP025981:25069-25554 [Escherichia marmotae]
MGCVTAPEPLSSFHQVAEFVSGEAVLDDWLKQKGLKNQALGATRTFVVCRKGTQQVVGFYSLATGSVNHTEATGNLRRNM
PNPIPVIILARLAVDASFRGKGLGADLLHDAVCRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKTQVQTLFLKLP
Q

Download         Length: 486 bp

>T92629 NZ_CP025981:25069-25554 [Escherichia marmotae]
ATGGGATGTGTAACAGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAGCTGTTCTTGA
TGACTGGTTAAAGCAGAAGGGGCTAAAAAATCAAGCTCTCGGAGCCACCCGGACTTTTGTTGTATGCAGGAAAGGTACGC
AACAAGTAGTCGGTTTTTACTCACTGGCTACTGGCAGTGTCAACCATACAGAAGCTACAGGTAATCTTCGGCGCAATATG
CCTAACCCCATCCCTGTCATTATACTTGCACGCCTGGCTGTTGATGCGTCATTCCGTGGTAAAGGGCTTGGTGCAGATTT
ACTGCATGATGCGGTTTGTCGTTGTTACAGAGTGGCCGAAAATATAGGTGTGCGTGCAATTATGGTTCATGCACTTACGG
AAAACGCAAAACAGTTTTATATTCACCATGGTTTTAAGCCATCAAAAACCCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10945.60 Da        Isoelectric Point: 4.6926

>AT92629 WP_101958039.1 NZ_CP025981:24797-25081 [Escherichia marmotae]
MIYGGFMKSGVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVTDEP
AIEKLLARKPQWDV

Download         Length: 285 bp

>AT92629 NZ_CP025981:24797-25081 [Escherichia marmotae]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAACTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGACAC
TGCTGCAGAAATTCTTCATAAGTCACGTACAGACTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATCGAAATGCTTGATGCTCCGGTTACAGATGAGCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References