Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4130759..4131410 Replicon chromosome
Accession NZ_CP025979
Organism Escherichia marmotae strain HT073016

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag C1192_RS21140 Protein ID WP_000244789.1
Coordinates 4131006..4131410 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag C1192_RS21135 Protein ID WP_000354045.1
Coordinates 4130759..4131025 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1192_RS21110 4126768..4128201 - 1434 WP_001517031.1 6-phospho-beta-glucosidase BglA -
C1192_RS21115 4128246..4128557 + 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
C1192_RS21120 4128720..4129379 + 660 WP_001517030.1 hemolysin III family protein -
C1192_RS21125 4129526..4130506 - 981 WP_000886070.1 tRNA-modifying protein YgfZ -
C1192_RS21135 4130759..4131025 + 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
C1192_RS21140 4131006..4131410 + 405 WP_000244789.1 protein YgfX Toxin
C1192_RS21145 4131444..4131965 - 522 WP_001055874.1 flavodoxin FldB -
C1192_RS21150 4132076..4132972 + 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
C1192_RS21155 4132997..4133707 + 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1192_RS21160 4133713..4135446 + 1734 WP_038355435.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T92626 WP_000244789.1 NZ_CP025979:4131006-4131410 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

>T92626 NZ_CP025979:4131006-4131410 [Escherichia marmotae]
GTGGTCCTGTGGCAATCTGAATTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCCTGCTGATTCATGGGCTGGTTGCCGC
AGTTATTTTACTCATGCCATGGCCACTTAGTTACACCCCGCTATGGCTGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATTCCCGTCAGGGAGAGATTCGCCTGCTGATGGATGGGCGTTTACGTTGGCAAGGACAG
GAATGGAGCATCGTCAAAACGCCGTGGATGATTAAAAGCGGCATGATGTTACGTTTACGTTCTGATAGCGGCAAACGTCA
GCATTTGTGGCTGGCAGCAGACAGCATGGACGAAGCCGAATGGCGTGATTTACGGCGAATTTTGTTACAGCAAGAGATAC
GATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT92626 WP_000354045.1 NZ_CP025979:4130759-4131025 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT92626 NZ_CP025979:4130759-4131025 [Escherichia marmotae]
ATGGATATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGCGACGATCCGGACC
TGTTCAACTGGCTGATGAATCATGGTAAACCTGCCGATGCAGAACTGGAAATGATGGTCAGACTCATTCAGACACGGAAC
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References