Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3781925..3782421 Replicon chromosome
Accession NZ_CP025979
Organism Escherichia marmotae strain HT073016

Toxin (Protein)


Gene name ghoT Uniprot ID A0A7U9DCZ4
Locus tag C1192_RS19355 Protein ID WP_001173345.1
Coordinates 3781925..3782098 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A7U9DAJ1
Locus tag C1192_RS19360 Protein ID WP_001517605.1
Coordinates 3782125..3782421 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1192_RS19345 3778595..3780052 + 1458 WP_038355158.1 dipeptide/tripeptide permease DtpC -
C1192_RS19350 3780289..3781806 + 1518 WP_038355159.1 lysine--tRNA ligase -
C1192_RS19355 3781925..3782098 - 174 WP_001173345.1 type V toxin-antitoxin system toxin GhoT Toxin
C1192_RS19360 3782125..3782421 - 297 WP_001517605.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
C1192_RS19365 3782649..3782921 - 273 WP_038355160.1 N-acetyltransferase -
C1192_RS19370 3782933..3783163 - 231 WP_000371696.1 (4Fe-4S)-binding protein -
C1192_RS19375 3783342..3784973 + 1632 WP_038355161.1 sensor histidine kinase -
C1192_RS19380 3784970..3785689 + 720 WP_038355162.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3773073..3782421 9348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T92625 WP_001173345.1 NZ_CP025979:c3782098-3781925 [Escherichia marmotae]
MALFSKILIFYVIGVNISFVIIWFLSHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T92625 NZ_CP025979:c3782098-3781925 [Escherichia marmotae]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTCTCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGCCTACCCGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11568.18 Da        Isoelectric Point: 4.0994

>AT92625 WP_001517605.1 NZ_CP025979:c3782421-3782125 [Escherichia marmotae]
MEGINRFKTYVVSFDYPSSYYSVFLRLRSLMYDMDFSSIVADEYGIPRQLNENAFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMIVDDYFRQFYK

Download         Length: 297 bp

>AT92625 NZ_CP025979:c3782421-3782125 [Escherichia marmotae]
ATGGAAGGTATAAACAGGTTCAAAACTTACGTCGTTTCTTTTGATTATCCATCATCTTATTACTCAGTTTTCTTAAGGTT
AAGGTCGTTAATGTATGATATGGATTTCTCCTCTATAGTTGCTGATGAATATGGAATACCACGACAATTGAATGAGAATG
CTTTCGCAATAACGACATCATTAGCCGCAAGTGAAATTGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCAGATATT
GATTTTGACCTCAACATTATGATAGTCGATGACTATTTCCGTCAGTTCTACAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DCZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAJ1

References