Detailed information of TA system TA092611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 967802..968440
• Replicon: chromosome
• Accession: NZ_CP025979
• Organism: Escherichia marmotae strain HT073016

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7U9DHD1
• Locus tag: C1192_RS05210
• Protein ID: WP_000813795.1
• Coordinates: 968264..968440 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C1192_RS05205
• Protein ID: WP_077627724.1
• Coordinates: 967802..968218 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1192_RS05185	962958..963899	-	942	WP_038355802.1	ABC transporter permease	-
C1192_RS05190	963900..964913	-	1014	WP_038355801.1	ABC transporter ATP-binding protein	-
C1192_RS05195	964930..966075	-	1146	WP_000047463.1	ABC transporter substrate-binding protein	-
C1192_RS05200	966314..967723	-	1410	WP_000760662.1	PLP-dependent aminotransferase family protein	-
C1192_RS05205	967802..968218	-	417	WP_077627724.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
C1192_RS05210	968264..968440	-	177	WP_000813795.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
C1192_RS05215	968662..968892	+	231	WP_000494240.1	DUF2554 family protein	-
C1192_RS05220	968986..970947	-	1962	WP_038355805.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
C1192_RS05225	971020..971556	-	537	WP_000429073.1	XRE family transcriptional regulator	-
C1192_RS05230	971609..972820	+	1212	WP_103194828.1	benzoate/H(+) symporter BenE family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6747.80 Da
• Isoelectric Point: 11.5666

>T92611 WP_000813795.1 NZ_CP025979:c968440-968264 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T92611 NZ_CP025979:c968440-968264 [Escherichia marmotae]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15250.62 Da
• Isoelectric Point: 4.5908

>AT92611 WP_077627724.1 NZ_CP025979:c968218-967802 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT92611 NZ_CP025979:c968218-967802 [Escherichia marmotae]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCCGAAGCGTTGAC
GCAGGGAGAAACGGTCGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAACTCATCCCGTTACCTTCGCCATTGAATAACAACGATCACTTTATTGAAGTACCTTTAAGTGTTGCTTCTAAGGTA
TTGCTGCTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A7U9DHD1