Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3981153..3981772 Replicon chromosome
Accession NZ_CP025963
Organism Klebsiella pneumoniae strain WCHKP020034

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CEA73_RS20100 Protein ID WP_002892050.1
Coordinates 3981554..3981772 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag CEA73_RS20095 Protein ID WP_002892066.1
Coordinates 3981153..3981527 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEA73_RS20085 3976305..3977498 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CEA73_RS20090 3977521..3980667 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
CEA73_RS20095 3981153..3981527 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
CEA73_RS20100 3981554..3981772 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CEA73_RS20105 3981935..3982501 + 567 WP_002892030.1 maltose O-acetyltransferase -
CEA73_RS29855 3982473..3982613 - 141 WP_004147370.1 hypothetical protein -
CEA73_RS20110 3982634..3983104 + 471 WP_020802585.1 YlaC family protein -
CEA73_RS20115 3983079..3984530 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
CEA73_RS20120 3984631..3985329 + 699 WP_023287311.1 GNAT family N-acetyltransferase -
CEA73_RS20125 3985326..3985466 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CEA73_RS20130 3985466..3985729 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T92602 WP_002892050.1 NZ_CP025963:3981554-3981772 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T92602 NZ_CP025963:3981554-3981772 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT92602 WP_002892066.1 NZ_CP025963:3981153-3981527 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT92602 NZ_CP025963:3981153-3981527 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References