Detailed information of TA system TA092587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2162649..2163435
• Replicon: chromosome
• Accession: NZ_CP025958
• Organism: Gemmata obscuriglobus strain DSM 5831

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: C1280_RS08820
• Protein ID: WP_010037297.1
• Coordinates: 2163001..2163435 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: C1280_RS08815
• Protein ID: WP_010037295.1
• Coordinates: 2162649..2162993 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1280_RS08810	2161214..2161735	-	522	WP_010037290.1	DUF3050 domain-containing protein	-
C1280_RS37770	2162456..2162647	-	192	WP_010037292.1	hypothetical protein	-
C1280_RS08815	2162649..2162993	+	345	WP_010037295.1	excisionase family DNA-binding protein	Antitoxin
C1280_RS08820	2163001..2163435	+	435	WP_010037297.1	PIN domain-containing protein	Toxin
C1280_RS08825	2164276..2166939	+	2664	WP_010037300.1	FkbM family methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• SinI-like, DNA-binding domain (45-89)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16615.84 Da
• Isoelectric Point: 6.2238

>T92587 WP_010037297.1 NZ_CP025958:2163001-2163435 [Gemmata obscuriglobus]
VSNFTALYDTCVLHLAPLRDFLMSRAEAKMFRARWTERIHEEWTRSLLEAANRPNPREARTHAAVDGCRGARLPHLRYED
LIDGLELPDPDDRQVLAATIRGRVDVIVMLNLKDFPPERRSPFGIEAHYPDVFIDHQLSLNQSD

Nucleotide

• Length: 435 bp

>T92587 NZ_CP025958:2163001-2163435 [Gemmata obscuriglobus]
GTGTCCAACTTTACGGCCCTTTACGACACCTGTGTCCTGCACCTCGCCCCGCTCCGCGACTTCCTCATGTCGCGCGCGGA
GGCGAAAATGTTCCGCGCGCGGTGGACGGAGCGCATCCACGAGGAATGGACGCGGAGCCTGCTGGAAGCAGCGAACCGAC
CTAACCCGCGAGAAGCTCGAACGCACGCGGCAGTTGATGGATGCCGCGGCGCCCGACTGCCTCATCTCCGGTACGAAGAC
CTGATCGACGGTCTCGAACTCCCGGACCCAGACGACCGGCAGGTCCTGGCCGCCACGATCCGCGGGCGGGTGGACGTGAT
CGTAATGCTCAACCTCAAGGACTTCCCGCCCGAGCGCCGTTCCCCGTTCGGAATCGAAGCCCATTACCCGGACGTGTTCA
TCGACCACCAGTTGAGCCTGAACCAATCGGACTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12649.44 Da
• Isoelectric Point: 6.0845

>AT92587 WP_010037295.1 NZ_CP025958:2162649-2162993 [Gemmata obscuriglobus]
VAVQENGKPGDVVAVSMAAFRLFTDILNAMARGDAGTIIPLHAELTTQQAADLLNVSRRYLVKLLERDEPSYHMVGTHRR
IKFHDLMAYSRVADEKRRQALDALAEEGEELGMG

Nucleotide

• Length: 345 bp

>AT92587 NZ_CP025958:2162649-2162993 [Gemmata obscuriglobus]
GTGGCCGTTCAGGAGAACGGGAAACCGGGCGACGTGGTGGCAGTGTCGATGGCCGCGTTCCGGCTGTTCACTGACATCCT
CAACGCGATGGCCCGCGGCGACGCGGGCACTATCATACCGCTGCACGCCGAGTTGACTACGCAACAGGCTGCAGACCTGC
TGAACGTGTCGCGCCGGTACCTCGTGAAACTGCTGGAGCGCGACGAACCGTCCTATCACATGGTCGGCACCCACCGACGA
ATCAAGTTCCACGACCTCATGGCATACTCTCGGGTCGCGGATGAGAAGCGGCGGCAGGCGCTCGACGCGCTGGCCGAAGA
GGGAGAAGAACTCGGAATGGGGTAA