Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4806096..4806750 Replicon chromosome
Accession NZ_CP025951
Organism Klebsiella pneumoniae subsp. pneumoniae strain GD4

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag CXZ11_RS24285 Protein ID WP_004144731.1
Coordinates 4806343..4806750 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CXZ11_RS24280 Protein ID WP_002916312.1
Coordinates 4806096..4806362 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXZ11_RS24255 4801252..4802685 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CXZ11_RS24260 4802804..4803532 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CXZ11_RS24265 4803582..4803893 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CXZ11_RS24270 4804057..4804716 + 660 WP_002916317.1 hemolysin III family protein -
CXZ11_RS24275 4804867..4805850 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CXZ11_RS24280 4806096..4806362 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CXZ11_RS24285 4806343..4806750 + 408 WP_004144731.1 protein YgfX Toxin
CXZ11_RS24290 4806757..4807278 - 522 WP_002916308.1 flavodoxin FldB -
CXZ11_RS24295 4807379..4808275 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CXZ11_RS24300 4808298..4809011 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CXZ11_RS24305 4809017..4810750 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T92576 WP_004144731.1 NZ_CP025951:4806343-4806750 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T92576 NZ_CP025951:4806343-4806750 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT92576 WP_002916312.1 NZ_CP025951:4806096-4806362 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT92576 NZ_CP025951:4806096-4806362 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References