Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1927455..1928290 Replicon chromosome
Accession NZ_CP025950
Organism Escherichia coli strain SCEC020023

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7X1VUT4
Locus tag C1A20_RS10750 Protein ID WP_025693544.1
Coordinates 1927455..1927832 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag C1A20_RS10755 Protein ID WP_001280951.1
Coordinates 1927922..1928290 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1A20_RS10710 1922975..1923448 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
C1A20_RS10715 1923646..1924704 + 1059 WP_001200895.1 FUSC family protein -
C1A20_RS10720 1924876..1925205 + 330 WP_000450409.1 DUF496 family protein -
C1A20_RS10725 1925306..1925488 - 183 WP_024174802.1 ethanolamine utilization protein -
C1A20_RS25440 1925942..1926313 - 372 WP_001295631.1 IS110 family transposase -
C1A20_RS25445 1927129..1927242 - 114 WP_032140621.1 DUF957 domain-containing protein -
C1A20_RS10745 1927255..1927458 - 204 WP_000761705.1 hypothetical protein -
C1A20_RS10750 1927455..1927832 - 378 WP_025693544.1 TA system toxin CbtA family protein Toxin
C1A20_RS10755 1927922..1928290 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C1A20_RS10760 1928453..1928674 - 222 WP_000692286.1 DUF987 domain-containing protein -
C1A20_RS10765 1928737..1929213 - 477 WP_001186747.1 RadC family protein -
C1A20_RS10770 1929229..1929702 - 474 WP_000855059.1 antirestriction protein -
C1A20_RS10780 1930044..1930862 - 819 WP_086714495.1 DUF945 domain-containing protein -
C1A20_RS10790 1931017..1931175 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galF / cpsACP / wzi / wza / gnd / wbtL / ugd / fyuA 1739735..1975168 235433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14039.01 Da        Isoelectric Point: 7.2919

>T92541 WP_025693544.1 NZ_CP025950:c1927832-1927455 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T92541 NZ_CP025950:c1927832-1927455 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT92541 WP_001280951.1 NZ_CP025950:c1928290-1927922 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT92541 NZ_CP025950:c1928290-1927922 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X1VUT4

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References