Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4309563..4310395 | Replicon | chromosome |
| Accession | NZ_CP025920 | ||
| Organism | Escherichia coli strain 103605 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | CXW53_RS21260 | Protein ID | WP_000854762.1 |
| Coordinates | 4309563..4309937 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | CXW53_RS21265 | Protein ID | WP_001295723.1 |
| Coordinates | 4310027..4310395 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CXW53_RS21220 | 4304630..4305307 | + | 678 | WP_001711999.1 | IS66 family insertion sequence hypothetical protein | - |
| CXW53_RS21225 | 4305307..4305654 | + | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CXW53_RS21230 | 4305674..4307245 | + | 1572 | WP_000381395.1 | IS66 family transposase | - |
| CXW53_RS21235 | 4307292..4307672 | + | 381 | WP_001171554.1 | IS66 family insertion sequence hypothetical protein | - |
| CXW53_RS21240 | 4307669..4308016 | + | 348 | WP_000612588.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CXW53_RS21245 | 4308066..4309127 | + | 1062 | Protein_4070 | IS66-like element ISEc8 family transposase | - |
| CXW53_RS21250 | 4309234..4309347 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| CXW53_RS21255 | 4309360..4309566 | - | 207 | WP_000976829.1 | hypothetical protein | - |
| CXW53_RS21260 | 4309563..4309937 | - | 375 | WP_000854762.1 | TA system toxin CbtA family protein | Toxin |
| CXW53_RS21265 | 4310027..4310395 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CXW53_RS21270 | 4310493..4310927 | + | 435 | WP_001403014.1 | IS66 family insertion sequence hypothetical protein | - |
| CXW53_RS21275 | 4310924..4311274 | + | 351 | WP_000624688.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CXW53_RS21280 | 4311305..4312918 | + | 1614 | WP_001744949.1 | IS66-like element ISEc47 family transposase | - |
| CXW53_RS21290 | 4313107..4313328 | - | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| CXW53_RS21295 | 4313391..4313867 | - | 477 | WP_001186774.1 | RadC family protein | - |
| CXW53_RS21300 | 4313883..4314356 | - | 474 | WP_000855059.1 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 4298668..4312918 | 14250 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14094.15 Da Isoelectric Point: 7.1881
>T92483 WP_000854762.1 NZ_CP025920:c4309937-4309563 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T92483 NZ_CP025920:c4309937-4309563 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT92483 WP_001295723.1 NZ_CP025920:c4310395-4310027 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT92483 NZ_CP025920:c4310395-4310027 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|