Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3290342..3290996 Replicon chromosome
Accession NZ_CP025920
Organism Escherichia coli strain 103605

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag CXW53_RS16315 Protein ID WP_000244781.1
Coordinates 3290589..3290996 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CXW53_RS16310 Protein ID WP_000354046.1
Coordinates 3290342..3290608 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXW53_RS16285 3285511..3286254 + 744 WP_000951961.1 SDR family oxidoreductase -
CXW53_RS16290 3286311..3287744 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
CXW53_RS16295 3287789..3288100 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
CXW53_RS16300 3288264..3288923 + 660 WP_000250274.1 hemolysin III family protein -
CXW53_RS16305 3289119..3290099 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
CXW53_RS16310 3290342..3290608 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CXW53_RS16315 3290589..3290996 + 408 WP_000244781.1 protein YgfX Toxin
CXW53_RS16320 3291036..3291557 - 522 WP_001055874.1 flavodoxin FldB -
CXW53_RS16325 3291669..3292565 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CXW53_RS16330 3292590..3293300 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CXW53_RS16335 3293306..3295039 + 1734 WP_000813218.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T92479 WP_000244781.1 NZ_CP025920:3290589-3290996 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T92479 NZ_CP025920:3290589-3290996 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT92479 WP_000354046.1 NZ_CP025920:3290342-3290608 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT92479 NZ_CP025920:3290342-3290608 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References