Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4275153..4275985 Replicon chromosome
Accession NZ_CP025916
Organism Escherichia coli strain 120899

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CXW56_RS21060 Protein ID WP_000854762.1
Coordinates 4275153..4275527 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag CXW56_RS21065 Protein ID WP_001295723.1
Coordinates 4275617..4275985 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXW56_RS21020 4270220..4270897 + 678 WP_001711999.1 IS66 family insertion sequence hypothetical protein -
CXW56_RS21025 4270897..4271244 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
CXW56_RS21030 4271264..4272835 + 1572 WP_000381395.1 IS66 family transposase -
CXW56_RS21035 4272882..4273262 + 381 WP_001171554.1 IS66 family insertion sequence hypothetical protein -
CXW56_RS21040 4273259..4273606 + 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
CXW56_RS21045 4273656..4274717 + 1062 Protein_4021 IS66-like element ISEc8 family transposase -
CXW56_RS21050 4274824..4274937 - 114 WP_001161660.1 DUF957 domain-containing protein -
CXW56_RS21055 4274950..4275156 - 207 WP_000976829.1 hypothetical protein -
CXW56_RS21060 4275153..4275527 - 375 WP_000854762.1 TA system toxin CbtA family protein Toxin
CXW56_RS21065 4275617..4275985 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXW56_RS21070 4276083..4276517 + 435 WP_001403014.1 IS66 family insertion sequence hypothetical protein -
CXW56_RS21075 4276514..4276864 + 351 WP_000624688.1 IS66 family insertion sequence element accessory protein TnpB -
CXW56_RS21080 4276895..4278508 + 1614 WP_001744949.1 IS66-like element ISEc47 family transposase -
CXW56_RS21090 4278697..4278918 - 222 WP_000692341.1 DUF987 domain-containing protein -
CXW56_RS21095 4278981..4279457 - 477 WP_001186774.1 RadC family protein -
CXW56_RS21100 4279473..4279946 - 474 WP_000855059.1 antirestriction protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4264258..4278508 14250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14094.15 Da        Isoelectric Point: 7.1881

>T92443 WP_000854762.1 NZ_CP025916:c4275527-4275153 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T92443 NZ_CP025916:c4275527-4275153 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT92443 WP_001295723.1 NZ_CP025916:c4275985-4275617 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT92443 NZ_CP025916:c4275985-4275617 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References