Detailed information of TA system TA092438

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3138078..3138876
• Replicon: chromosome
• Accession: NZ_CP025916
• Organism: Escherichia coli strain 120899

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CXW56_RS15465
• Protein ID: WP_000854733.1
• Coordinates: 3138078..3138455 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CXW56_RS15470
• Protein ID: WP_032190265.1
• Coordinates: 3138502..3138876 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXW56_RS15440	3133970..3134506	+	537	WP_000942799.1	GspM family type II secretion system protein YghD	-
CXW56_RS15445	3134841..3136376	-	1536	WP_000484448.1	EAL domain-containing protein	-
CXW56_RS27680	3136447..3137295	-	849	Protein_2946	DUF4942 domain-containing protein	-
CXW56_RS15455	3137384..3137581	-	198	WP_000839243.1	DUF957 domain-containing protein	-
CXW56_RS15460	3137593..3138081	-	489	WP_000761663.1	hypothetical protein	-
CXW56_RS15465	3138078..3138455	-	378	WP_000854733.1	TA system toxin CbtA family protein	Toxin
CXW56_RS15470	3138502..3138876	-	375	WP_032190265.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CXW56_RS15475	3138926..3139570	-	645	WP_000086771.1	hypothetical protein	-
CXW56_RS15480	3139589..3139810	-	222	WP_000692327.1	DUF987 domain-containing protein	-
CXW56_RS15485	3139873..3140349	-	477	WP_001502867.1	RadC family protein	-
CXW56_RS15490	3140365..3140838	-	474	WP_001355870.1	antirestriction protein	-
CXW56_RS15495	3140907..3141176	-	270	WP_001183319.1	hypothetical protein	-
CXW56_RS15500	3141176..3142006	-	831	WP_024172271.1	DUF945 domain-containing protein	-
CXW56_RS15505	3142021..3143592	-	1572	WP_000381395.1	IS66 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14236.21 Da
• Isoelectric Point: 6.8528

>T92438 WP_000854733.1 NZ_CP025916:c3138455-3138078 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T92438 NZ_CP025916:c3138455-3138078 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTACTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13967.80 Da
• Isoelectric Point: 6.7388

>AT92438 WP_032190265.1 NZ_CP025916:c3138876-3138502 [Escherichia coli]
VSDKLHETNYPDDHNDRIWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADSLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT92438 NZ_CP025916:c3138876-3138502 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCATCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA