Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2424124..2424742 Replicon chromosome
Accession NZ_CP025913
Organism Escherichia coli strain 203740

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CXW72_RS11825 Protein ID WP_001291435.1
Coordinates 2424124..2424342 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CXW72_RS11830 Protein ID WP_000344800.1
Coordinates 2424368..2424742 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXW72_RS11790 2419413..2419985 + 573 WP_000779831.1 YbaY family lipoprotein -
CXW72_RS11795 2420016..2420327 - 312 WP_000409911.1 MGMT family protein -
CXW72_RS11805 2420706..2421059 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CXW72_RS11810 2421101..2422651 - 1551 WP_001727568.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CXW72_RS11815 2422815..2423285 - 471 WP_000136192.1 YlaC family protein -
CXW72_RS11820 2423401..2423952 - 552 WP_001727569.1 maltose O-acetyltransferase -
CXW72_RS11825 2424124..2424342 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CXW72_RS11830 2424368..2424742 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CXW72_RS11835 2425288..2428437 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
CXW72_RS11840 2428460..2429653 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T92410 WP_001291435.1 NZ_CP025913:c2424342-2424124 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T92410 NZ_CP025913:c2424342-2424124 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT92410 WP_000344800.1 NZ_CP025913:c2424742-2424368 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT92410 NZ_CP025913:c2424742-2424368 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References