Detailed information of TA system TA092376

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2004141..2004939
• Replicon: chromosome
• Accession: NZ_CP025910
• Organism: Escherichia coli strain 204446

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CXW77_RS09765
• Protein ID: WP_000854733.1
• Coordinates: 2004141..2004518 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CXW77_RS09770
• Protein ID: WP_032190265.1
• Coordinates: 2004565..2004939 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXW77_RS09740	2000033..2000569	+	537	WP_000942799.1	GspM family type II secretion system protein YghD	-
CXW77_RS09745	2000904..2002439	-	1536	WP_000484448.1	EAL domain-containing protein	-
CXW77_RS27250	2002510..2003358	-	849	Protein_1867	DUF4942 domain-containing protein	-
CXW77_RS09755	2003447..2003644	-	198	WP_000839243.1	DUF957 domain-containing protein	-
CXW77_RS09760	2003656..2004144	-	489	WP_000761663.1	hypothetical protein	-
CXW77_RS09765	2004141..2004518	-	378	WP_000854733.1	TA system toxin CbtA family protein	Toxin
CXW77_RS09770	2004565..2004939	-	375	WP_032190265.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CXW77_RS09775	2004989..2005633	-	645	WP_000086771.1	hypothetical protein	-
CXW77_RS09780	2005652..2005873	-	222	WP_000692327.1	DUF987 domain-containing protein	-
CXW77_RS09785	2005936..2006412	-	477	WP_001502867.1	RadC family protein	-
CXW77_RS09790	2006428..2006901	-	474	WP_001355870.1	antirestriction protein	-
CXW77_RS09795	2006970..2007239	-	270	WP_001183319.1	hypothetical protein	-
CXW77_RS09800	2007239..2008069	-	831	WP_024172271.1	DUF945 domain-containing protein	-
CXW77_RS09805	2008084..2009655	-	1572	WP_000381395.1	IS66 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14236.21 Da
• Isoelectric Point: 6.8528

>T92376 WP_000854733.1 NZ_CP025910:c2004518-2004141 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T92376 NZ_CP025910:c2004518-2004141 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTACTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13967.80 Da
• Isoelectric Point: 6.7388

>AT92376 WP_032190265.1 NZ_CP025910:c2004939-2004565 [Escherichia coli]
VSDKLHETNYPDDHNDRIWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADSLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT92376 NZ_CP025910:c2004939-2004565 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCATCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA